SCHEMBL8060466

SCHEMBL8060466

Cc1cccc(C(F)(F)F)c1C=CC(=O)O

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NFKB1 P19838 1/20 0.42
MAOB P27338 5/20 0.40
HDAC3 O15379 1/20 0.39
TNKS O95271 1/20 0.39
HDAC4 P56524 1/20 0.39
HDAC1 Q13547 1/20 0.39
HCAR2 Q8TDS4 1/20 0.39
HDAC7 Q8WUI4 1/20 0.39
HDAC2 Q92769 1/20 0.39
HDAC10 Q969S8 1/20 0.39
HDAC11 Q96DB2 1/20 0.39
HDAC8 Q9BY41 1/20 0.39
TNKS2 Q9H2K2 1/20 0.39
HDAC6 Q9UBN7 1/20 0.39
HDAC9 Q9UKV0 1/20 0.39
HDAC5 Q9UQL6 1/20 0.39
ALDH1A1 P00352 4/20 0.39
KDM4E B2RXH2 3/20 0.39
GAA P10253 1/20 0.39
ATM Q13315 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8058605 0.83 MAOB (0.46) NFKB1MAOBALDH1A1KDM4EGAA
SCHEMBL2059374 0.82 HCAR2 (0.50) NFKB1HDAC3TNKSHDAC4HDAC1
SCHEMBL2059378 0.82 HCAR2 (0.50) NFKB1HDAC3TNKSHDAC4HDAC1
SCHEMBL6284514 0.82 ABCG2 (0.44) NFKB1MAOBHDAC3TNKSHDAC4
SCHEMBL6284512 0.82 ABCG2 (0.44) NFKB1MAOBHDAC3TNKSHDAC4
SCHEMBL3712675 0.81 NFKB1 (0.42) NFKB1MAOBHDAC3TNKSHDAC4
SCHEMBL3712676 0.81 NFKB1 (0.42) NFKB1MAOBHDAC3TNKSHDAC4
SCHEMBL11834874 0.76 CA1 (0.52) NFKB1MAOBHDAC3TNKSHDAC4
SCHEMBL8111349 0.75 ALDH1A1 (0.39) NFKB1ALDH1A1KDM4EGAAATM
SCHEMBL3645896 0.75 MAOB (0.45) NFKB1MAOBHDAC3TNKSHDAC4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6127392-A A MUSCLE RELAXANT FOR TREATMENT OF DISORDERS ASSOCIATED WITH SMOOTH MUSCLE CONTRACTION VIA POTASSIUM CHANNEL AND CHLORIDE CHANNEL MODULATION; INOTROPIC AGENT AMERICAN HOME PRODUCTS CORPORATION (US) 2000-10-03 US disclosed
EP-1003712-A1 ANTHRANILIC ACID ANALOGS AMERICAN HOME PRODUCTS CORPORATION (US) 2000-05-31 EP disclosed
US-6046239-A USED IN THE TREATMENT OF DISORDERS ASSOCIATED WITH SMOOTH MUSCLE CONTRACTION, VIA POTASSIUM CHANNEL AND CHLORIDE CHANNEL MODULATION SUCH AS URINARY INCONTINENCE, ASTHMA, ANGINA, PREMATURE LABOR, CONGESTIVE HEART FAILURE AMERICAN HOME PRODUCTS CORPORATION (US) 2000-04-04 US disclosed
WO-1999007669-A1 ANTHRANILIC ACID ANALOGS AMERICAN HOME PRODUCTS CORPORATION (US) 1999-02-18 WO disclosed