Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.67 |
| ▸ | CA2 | P00918 | 1/20 | 0.59 |
| ▸ | CA4 | P22748 | 1/20 | 0.59 |
| ▸ | CA5A | P35218 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | ALPG | P10696 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | NPY1R | P25929 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | NPY2R | P49146 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | PTPN2 | P17706 | 3/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14287997 | 0.90 | CFTR (0.82) | CFTRALDH1A1CA2CA4CA5A | |
| SCHEMBL171269 | 0.88 | CFTR (0.78) | CFTRALDH1A1CA2CA4CA5A | |
| SCHEMBL752882 | 0.88 | CFTR (0.78) | CFTRALDH1A1CA2CA4CA5A | |
| Phosphine SCHEMBL27883782 | 0.86 | CFTR (0.75) | CFTRALDH1A1CA2CA4CA5A | |
| SCHEMBL14809684 | 0.86 | CFTR (0.75) | CFTRALDH1A1CA2CA4CA5A | |
| SCHEMBL14287993 | 0.86 | CFTR (0.75) | CFTRALDH1A1CA2CA4CA5A | |
| SCHEMBL17488952 | 0.84 | CFTR (0.72) | CFTRALDH1A1CA2CA4CA5A | |
| SCHEMBL65139 | 0.84 | CFTR (0.72) | CFTRALDH1A1CA2CA4CA5A | |
| SCHEMBL19773247 | 0.84 | CFTR (0.72) | CFTRALDH1A1CA2CA4CA5A | |
| SCHEMBL17488959 | 0.84 | CFTR (0.72) | CFTRALDH1A1CA2CA4CA5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10463639-B2 | Compounds as modulators of a mutant CFTR protein and their use for treating diseases associated with CFTR protein malfunction | INSTYTUT BIOCHEMII I BIOFIZYKI PAN (PL) | 2019-11-05 | — | — | US | disclosed |
| US-10463639-B2 | Compounds as modulators of a mutant CFTR protein and their use for treating diseases associated with CFTR protein malfunction | INSTYTUT BIOCHEMII I BIOFIZYKI PAN (PL) | 2019-11-05 | — | — | US | disclosed |
| US-10420738-B2 | Compounds as modulators of a mutant CFTR protein and their use for treating diseases associated with CFTR protein malfunction | INSTYTUT BIOCHEMII I BIOFIZYKI PAN (PL) | 2019-09-24 | — | — | US | disclosed |
| US-10398665-B2 | Compounds as modulators of a mutant CFTR protein and their use for treating diseases associated with CFTR protein malfunction | INSTYTUT BIOCHEMII I BIOFIZYKI PAN (PL) | 2019-09-03 | — | — | US | disclosed |
| US-10398665-B2 | Compounds as modulators of a mutant CFTR protein and their use for treating diseases associated with CFTR protein malfunction | INSTYTUT BIOCHEMII I BIOFIZYKI PAN (PL) | 2019-09-03 | — | — | US | disclosed |
| EP-2816034-B1 | COMPOUNDS AS MODULATORS OF A MUTANT CFTR PROTEIN AND THEIR USE FOR TREATING DISEASES ASSOCIATED WITH CFTR PROTEIN MALFUNCTION | INST BIOCHEMII I BIOFIZYKI POLSKIEJ AKADEMII NAUK (PL) | 2018-12-12 | — | — | EP | disclosed |
| EP-2826771-B1 | Compounds as modulators of a mutant CFTR protein and their use for treating diseases associated with CFTR protein malfunction | INST BIOCHEMII I BIOFIZYKI POLSKIEJ AKADEMII NAUK (PL) | 2018-12-12 | — | — | EP | disclosed |
| US-9826129-B2 | Near-infrared-ray-absorbing composition, near-infrared-ray cut filter using same, manufacturing method therefor, camera module, and manufacturing method therefor | FUJIFILM CORPORATION (JP) | 2017-11-21 | — | — | US | disclosed |
| US-9826129-B2 | Near-infrared-ray-absorbing composition, near-infrared-ray cut filter using same, manufacturing method therefor, camera module, and manufacturing method therefor | FUJIFILM CORPORATION (JP) | 2017-11-21 | — | — | US | disclosed |
| US-20160113896-A1 | COMPOUNDS AS MODULATORS OF A MUTANT CFTR PROTEIN AND THEIR USE FOR TREATING DISEASES ASSOCIATED WITH CFTR PROTEIN MALFUNCTION | INSTYTUT BIOCHEMII I BIOFIZYKI PAN (PL) | 2016-04-28 | — | — | US | disclosed |
| EP-2616444-B1 | COMPOUNDS AS MODULATORS OF A MUTANT CFTR PROTEIN AND THEIR USE FOR TREATING DISEASES ASSOCIATED WITH CFTR PROTEIN MALFUNCTION | INST BIOCHEMII I BIOFIZYKI PAN (PL) | 2015-08-26 | — | — | EP | disclosed |
| EP-2616444-B1 | COMPOUNDS AS MODULATORS OF A MUTANT CFTR PROTEIN AND THEIR USE FOR TREATING DISEASES ASSOCIATED WITH CFTR PROTEIN MALFUNCTION | INST BIOCHEMII I BIOFIZYKI PAN (PL) | 2015-08-26 | — | — | EP | disclosed |
| EP-2826771-A2 | Compounds as modulators of a mutant CFTR protein and their use for treating diseases associated with CFTR protein malfunction | Instytut Biochemii I Biofizyki Polskiej Akademii Nauk (PL) | 2015-01-21 | — | — | EP | disclosed |
| EP-2816035-A2 | Compounds as modulators of a mutant CFTR protein and their use for treating diseases associated with CFTR protein malfunction | Instytut Biochemii I Biofizyki Polskiej Akademii Nauk (PL) | 2014-12-24 | — | — | EP | disclosed |
| EP-2816034-A2 | Compounds as modulators of a mutant CFTR protein and their use for treating diseases associated with CFTR protein malfunction | Instytut Biochemii I Biofizyki Polskiej Akademii Nauk (PL) | 2014-12-24 | — | — | EP | disclosed |
| US-20130303761-A1 | COMPOUNDS AS MODULATORS OF A MUTANT CFTR PROTEIN AND THEIR USE FOR TREATING DISEASES ASSOCIATED WITH CFTR PROTEIN MALFUNCTION | INSTYTUT BIOCHEMII I BIOFIZYKI PAN (PL) | 2013-11-14 | — | — | US | disclosed |
| US-20130303761-A1 | COMPOUNDS AS MODULATORS OF A MUTANT CFTR PROTEIN AND THEIR USE FOR TREATING DISEASES ASSOCIATED WITH CFTR PROTEIN MALFUNCTION | INSTYTUT BIOCHEMII I BIOFIZYKI PAN (PL) | 2013-11-14 | — | — | US | disclosed |
| WO-2012036573-A2 | COMPOUNDS AS MODULATORS OF A MUTANT CFTR PROTEIN AND THEIR USE FOR TREATING DISEASES ASSOCIATED WITH CFTR PROTEIN MALFUNCTION | INSTYTUT BIOCHEMII I BIOFIZYKI PAN (PL) | 2012-03-22 | — | — | WO | disclosed |
| EP-0006568-A1 | Flame-retarding agents and their use in the preparation of fire-proof thermoplastic polymers | HOECHST AKTIENGESELLSCHAFT (DE) | 1980-01-09 | — | — | EP | disclosed |
| US-3962194-A | FILAMENTS, FIBERS | HOECHST AKTIENGESELLSCHAFT (DT) | 1976-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10398665-B2 | Compounds as modulators of a mutant CFTR protein and their use for treating diseases associated with CFTR protein malfunction | CFTR, TMEM161A, TMEM120A | CFTR 1/4885ALDH1A1 3701/4885CA2 2128/4885 |
| US-10420738-B2 | Compounds as modulators of a mutant CFTR protein and their use for treating diseases associated with CFTR protein malfunction | CFTR, TMEM161A, TCOF1 | CFTR 1/4885ALDH1A1 3883/4885CA2 2129/4885 |
| US-20130303761-A1 | COMPOUNDS AS MODULATORS OF A MUTANT CFTR PROTEIN AND THEIR USE FOR TREATING DISEASES ASSOCIATED WITH CFTR PROTEIN MALFUNCTION | CFTR, TCOF1, ABCC2 | CFTR 1/4885ALDH1A1 4338/4885CA2 2394/4885 |
| US-20160113896-A1 | COMPOUNDS AS MODULATORS OF A MUTANT CFTR PROTEIN AND THEIR USE FOR TREATING DISEASES ASSOCIATED WITH CFTR PROTEIN MALFUNCTION | CFTR, TMEM161A, TCOF1 | CFTR 1/4885ALDH1A1 3883/4885CA2 2129/4885 |
| US-10463639-B2 | Compounds as modulators of a mutant CFTR protein and their use for treating diseases associated with CFTR protein malfunction | CFTR, TMEM161A, TCOF1 | CFTR 1/4885ALDH1A1 3883/4885CA2 2129/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.