Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 3/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8058099 | 0.85 | RAB9A (0.38) | RAB9AMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL8045201 | 0.81 | TSHR (0.34) | RAB9ATSHRKMT2AALDH1A1HPGD | |
| SCHEMBL8058197 | 0.80 | — | — | |
| SCHEMBL8060815 | 0.79 | KDM4E (0.38) | RAB9ATSHRMEN1KMT2AALDH1A1 | |
| SCHEMBL8062781 | 0.78 | ALDH1A1 (0.36) | TSHRKMT2AALDH1A1HPGDGAA | |
| SCHEMBL8057027 | 0.78 | RAB9A (0.43) | RAB9AMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL8056335 | 0.77 | ALDH1A1 (0.35) | RAB9ATSHRALDH1A1HPGDKDM4E | |
| SCHEMBL8056280 | 0.77 | KDM4E (0.43) | RAB9ATSHRMEN1KMT2AALDH1A1 | |
| SCHEMBL8062947 | 0.76 | CA12 (0.36) | RAB9ATSHRALDH1A1HPGDKDM4E | |
| SCHEMBL8062773 | 0.75 | TSHR (0.34) | TSHRALDH1A1HPGDGAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6028069-A | Heterocyclyl-condensed benzoylguanidines, their production and use as inhibitors of the cellular Na+/H+-antiporter | MERCK PATENT GESELLSCHAFT MIT BERSCHRANKER HAFTUNG (DE) | 2000-02-22 | — | — | US | disclosed |