Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8060815 | 0.86 | KDM4E (0.38) | KDM4EALDH1A1GPR119MAPTSMN1; SMN2 | |
| SCHEMBL8056203 | 0.84 | ALDH1A1 (0.44) | KDM4EALDH1A1MTNR1AGPR119MAPT | |
| SCHEMBL8057351 | 0.79 | — | — | |
| SCHEMBL8062947 | 0.78 | CA12 (0.36) | KDM4EALDH1A1MAPTSMN1; SMN2HSD17B10 | |
| SCHEMBL8060881 | 0.77 | ALDH1A1 (0.35) | KDM4EALDH1A1MAPTSMN1; SMN2KMT2A | |
| SCHEMBL8062814 | 0.77 | ALDH1A1 (0.35) | KDM4EALDH1A1MAPTSMN1; SMN2KMT2A | |
| SCHEMBL8045260 | 0.77 | ALDH1A1 (0.33) | KDM4EALDH1A1MAPTSMN1; SMN2KMT2A | |
| SCHEMBL8060520 | 0.77 | RAB9A (0.35) | KDM4EALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL8060801 | 0.77 | CTSL (0.34) | KDM4EALDH1A1GPR119MAPTPOLB | |
| SCHEMBL8060804 | 0.75 | CYP2C9 (0.46) | KDM4EALDH1A1MAPTSMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6028069-A | Heterocyclyl-condensed benzoylguanidines, their production and use as inhibitors of the cellular Na+/H+-antiporter | MERCK PATENT GESELLSCHAFT MIT BERSCHRANKER HAFTUNG (DE) | 2000-02-22 | — | — | US | disclosed |