Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 11/20 | 0.43 |
| ▸ | MMP12 | P39900 | 10/20 | 0.43 |
| ▸ | MMP9 | P14780 | 10/20 | 0.43 |
| ▸ | MMP8 | P22894 | 9/20 | 0.43 |
| ▸ | MMP13 | P45452 | 9/20 | 0.43 |
| ▸ | MMP14 | P50281 | 8/20 | 0.43 |
| ▸ | MMP16 | P51512 | 8/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MMP3 | P08254 | 5/20 | 0.41 |
| ▸ | MMP1 | P03956 | 4/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7542283 | 0.77 | PTPN1 (0.54) | CNR1HSD11B1KMT2APKMSMN1; SMN2 | |
| SCHEMBL2900573 | 0.74 | KMT2A (0.67) | MMP2MMP12MMP9MMP8MMP13 | |
| SCHEMBL7533431 | 0.73 | PKM (0.47) | MMP2MMP12MMP9MMP8MMP13 | |
| SCHEMBL11799574 | 0.72 | TSHR (0.43) | KMT2ASMN1; SMN2 | |
| SCHEMBL7534402 | 0.69 | ALDH1A1 (0.61) | KMT2ASMN1; SMN2 | |
| SCHEMBL14553430 | 0.68 | PKM (0.58) | HSD11B1KMT2APKMSMN1; SMN2 | |
| SCHEMBL27746984 | 0.67 | ELANE (0.48) | CA2SMN1; SMN2ELANE | |
| SCHEMBL4615874 | 0.66 | PKM (0.51) | HSD11B1KMT2APKMSMN1; SMN2 | |
| SCHEMBL28311451 | 0.66 | HSD11B1 (0.61) | MMP2MMP12MMP9MMP8MMP13 | |
| SCHEMBL29057923 | 0.66 | PKM (0.50) | MMP2MMP12MMP9MMP8MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1005453-A1 | SUBSTITUTED BENZENE COMPOUNDS AS ANTIPROLIFERATIVE AND CHOLESTEROL LOWERING AGENTS | TULARIK, INC. (US) | 2000-06-07 | — | — | EP | claimed |
| WO-1999010320-A1 | SUBSTITUTED BENZENE COMPOUNDS AS ANTIPROLIFERATIVE AND CHOLESTEROL LOWERING AGENTS | TULARIK INC. (US) | 1999-03-04 | — | — | WO | claimed |