Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 3/20 | 0.32 |
| ▸ | MMP1 | P03956 | 2/20 | 0.31 |
| ▸ | MMP9 | P14780 | 2/20 | 0.31 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | CASP7 | P55210 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8057009 | 0.84 | MAPT (0.37) | MMP2ALDH1A1MAPTLMNAIRAK4 | |
| SCHEMBL8062949 | 0.81 | ALDH1A1 (0.34) | MMP2ALDH1A1MAPTLMNAKMT2A | |
| SCHEMBL8045314 | 0.77 | ALDH1A1 (0.34) | ALDH1A1MAPTLMNAKMT2AKDM4E | |
| SCHEMBL8056504 | 0.77 | IRAK4 (0.35) | ALDH1A1MAPTLMNAIRAK4KMT2A | |
| SCHEMBL8060801 | 0.77 | CTSL (0.34) | ALDH1A1MAPTLMNAKDM4EHSD17B10 | |
| SCHEMBL8045218 | 0.75 | CA1 (0.42) | ALDH1A1MAPTLMNAKMT2AKDM4E | |
| SCHEMBL18581885 | 0.75 | ALDH1A1 (0.47) | MMP2ALDH1A1MAPTLMNAKMT2A | |
| SCHEMBL8045118 | 0.75 | LMNA (0.40) | ALDH1A1MAPTLMNAKMT2AKDM4E | |
| SCHEMBL8056269 | 0.74 | ALDH1A1 (0.35) | ALDH1A1MAPTLMNAKMT2AKDM4E | |
| SCHEMBL8058163 | 0.74 | CTSL (0.37) | ALDH1A1MAPTLMNAKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6028069-A | Heterocyclyl-condensed benzoylguanidines, their production and use as inhibitors of the cellular Na+/H+-antiporter | MERCK PATENT GESELLSCHAFT MIT BERSCHRANKER HAFTUNG (DE) | 2000-02-22 | — | — | US | disclosed |