Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.56 |
| ▸ | ESR1 | P03372 | 4/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 8/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20626551 | 1.00 | HSD11B1 (0.56) | HSD11B1ESR1ESR2CYP19A1MAPT | |
| SCHEMBL20626553 | 1.00 | HSD11B1 (0.56) | HSD11B1ESR1ESR2CYP19A1MAPT | |
| SCHEMBL14190664 | 1.00 | HSD11B1 (0.56) | HSD11B1ESR1ESR2CYP19A1MAPT | |
| SCHEMBL6345133 | 1.00 | HSD11B1 (0.56) | HSD11B1ESR1ESR2CYP19A1MAPT | |
| SCHEMBL6343327 | 1.00 | HSD11B1 (0.56) | HSD11B1ESR1ESR2CYP19A1MAPT | |
| SCHEMBL20626528 | 0.91 | HSD11B1 (0.53) | HSD11B1ESR1ESR2CYP19A1MAPT | |
| SCHEMBL20626552 | 0.91 | HSD11B1 (0.53) | HSD11B1ESR1ESR2CYP19A1MAPT | |
| SCHEMBL6346483 | 0.91 | HSD11B1 (0.53) | HSD11B1ESR1ESR2CYP19A1MAPT | |
| SCHEMBL806080 | 0.91 | HSD11B1 (0.53) | HSD11B1ESR1ESR2CYP19A1MAPT | |
| SCHEMBL20626554 | 0.91 | HSD11B1 (0.53) | HSD11B1ESR1ESR2CYP19A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9636348-B2 | 6-substituted estradiol derivatives for use in remyelination of nerve axons | ENDECE LLC (US) | 2017-05-02 | — | — | US | disclosed |
| EP-2616477-B1 | 6-SUBSTITUTED DEMETHYL-ESTRADIOL DERIVATIVES AS ER-BETA AGONISTS | ENDECE LLC (US) | 2016-11-09 | — | — | EP | disclosed |
| US-20160279144-A1 | 6-Substituted Estradiol Derivatives for Use in Remyelination of Nerve Axons | ENDECE LLC | 2016-09-29 | — | — | US | disclosed |
| EP-2099460-B1 | 6-ALKOXYALKYL ESTRADIOL DERIVATIVES AND METHODS OF USE | ENDECE LLC (US) | 2016-09-07 | — | — | EP | disclosed |
| US-9422324-B2 | 6-substituted demethyl-estradiol derivatives as selective ER-β agonists | ENDECE LLC (US) | 2016-08-23 | — | — | US | disclosed |
| EP-2507253-B1 | 6-SUBSTITUTED ESTRADIOL DERIVATIVES AND METHODS OF USE | ENDECE LLC (US) | 2016-03-30 | — | — | EP | disclosed |
| EP-2688570-B1 | 6-SUBSTITUTED ESTRADIOL DERIVATIVES FOR USE IN REMYELINATION OF NERVE AXONS | ENDECE LLC (US) | 2015-11-18 | — | — | EP | disclosed |
| WO-2015143201-A2 | 6-SUBSTITUTED ESTRADIOL DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | ENDECE LLC (US) | 2015-09-24 | — | — | WO | disclosed |
| US-20150265630-A1 | 6-Substituted Estradiol Derivatives for the Treatment of Alzheimer's Disease | ENDECE LLC | 2015-09-24 | — | — | US | disclosed |
| US-20140315874-A1 | 6-Substituted Demethyl-Estradiol Derivatives as Selective ER-Beta Agonists | ENDECE, LLC | 2014-10-23 | — | — | US | disclosed |
| US-8168621-B2 | 6-substituted estradiol derivatives and methods of use | ENDECE, LLC (US) | 2012-05-01 | — | — | US | disclosed |
| US-20120071455-A1 | 6-SUBSTITUTED DEMETHYL-ESTRADIOL DERIVATIVES AS SELECTIVE ER-BETA AGONISTS | ENDECE, LLC | 2012-03-22 | — | — | US | disclosed |
| WO-2012037261-A2 | 6-SUBSTITUTED DEMETHYL-ESTRADIOL DERIVATIVES AS ER-BETA AGONISTS | ENDECE, LLC (US) | 2012-03-22 | — | — | WO | disclosed |
| WO-2011066542-A2 | 6-SUBSTITUTED ESTRADIOL DERIVATIVES AND METHODS OF USE | ENDECE INC. (US) | 2011-06-03 | — | — | WO | disclosed |
| US-20100130463-A1 | 6-SUBSTITUTED ESTRADIOL DERIVATIVES AND METHODS OF USE | ENDECE, LLC | 2010-05-27 | — | — | US | disclosed |
| WO-2009149176-A1 | 6-SUBSTITUTED ESTRADIOL DERIVATIVES AND METHODS OF USE | ENDECE, LLC (US) | 2009-12-10 | — | — | WO | disclosed |
| US-20080312202-A1 | 6-SUBSTITUTED ESTRADIOL DERIVATIVES AND METHODS OF USE | ENDECE, LLC | 2008-12-18 | — | — | US | disclosed |
| US-20080312202-A1 | 6-SUBSTITUTED ESTRADIOL DERIVATIVES AND METHODS OF USE | ENDECE, LLC | 2008-12-18 | — | — | US | disclosed |
| WO-2008067450-A2 | 6-ALKOXYALKYL ESTRADIOL DERIVATIVES AND METHODS OF USE | ENDECE, LLC (US) | 2008-06-05 | — | — | WO | disclosed |
| US-20080119447-A1 | 6-ALKOXYALKYL ESTRADIOL DERIVATIVES AND METHODS OF USE | ENDECE LLC | 2008-05-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080312202-A1 | 6-SUBSTITUTED ESTRADIOL DERIVATIVES AND METHODS OF USE | SHBG, NR5A1, SULT2A1 | HSD11B1 125/4885ESR1 26/4885ESR2 13/4885 |
| US-20140315874-A1 | 6-Substituted Demethyl-Estradiol Derivatives as Selective ER-Beta Agonists | ESR2, ESR1, ESRRG | HSD11B1 302/4885ESR1 2/4885ESR2 1/4885 |
| US-20080119447-A1 | 6-ALKOXYALKYL ESTRADIOL DERIVATIVES AND METHODS OF USE | SHBG, HSD17B11, ESRRA | HSD11B1 49/4885ESR1 4/4885ESR2 6/4885 |
| US-20150265630-A1 | 6-Substituted Estradiol Derivatives for the Treatment of Alzheimer's Disease | HSD17B11, ESR2, PSEN2 | HSD11B1 78/4885ESR1 13/4885ESR2 2/4885 |
| US-20120071455-A1 | 6-SUBSTITUTED DEMETHYL-ESTRADIOL DERIVATIVES AS SELECTIVE ER-BETA AGONISTS | ESR2, ESR1, ESRRG | HSD11B1 302/4885ESR1 2/4885ESR2 1/4885 |
| US-20160279144-A1 | 6-Substituted Estradiol Derivatives for Use in Remyelination of Nerve Axons | PMP22, GAP43, MAG | HSD11B1 833/4885ESR1 199/4885ESR2 13/4885 |
| US-20100130463-A1 | 6-SUBSTITUTED ESTRADIOL DERIVATIVES AND METHODS OF USE | NR3C2, SHBG, ESR2 | HSD11B1 48/4885ESR1 17/4885ESR2 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.