Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | RGS12 | O14924 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 7/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | POLB | P06746 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9805593 | 0.80 | ALDH1A1 (0.61) | ALDH1A1MAPTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL3764555 | 0.79 | RAB9A (0.60) | ALDH1A1MAPTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL14624712 | 0.79 | ALDH1A1 (0.60) | ALDH1A1MAPTRAB9ASMN1; SMN2NPC1 | |
| Hydrochloric Acid SCHEMBL7423557 | 0.78 | RAB9A (0.58) | ALDH1A1MAPTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL10402107 | 0.75 | RAB9A (0.50) | ALDH1A1MAPTRGS12RAB9ASMN1; SMN2 | |
| SCHEMBL10402108 | 0.75 | RAB9A (0.50) | ALDH1A1MAPTRGS12RAB9ASMN1; SMN2 | |
| SCHEMBL1046695 | 0.73 | TBXAS1 (0.44) | ALDH1A1MAPTRGS12SMN1; SMN2LMNA | |
| SCHEMBL10403280 | 0.73 | MAPT (0.55) | ALDH1A1MAPTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL13416227 | 0.73 | — | — | |
| SCHEMBL28476855 | 0.72 | KDM6B (0.45) | ALDH1A1MAPTRGS12RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080768-A | USEFUL IN THE TREATMENT OF ARTERIAL HYPERTENSION AND HEART FAILURE, RENAL INSUFFICIENCY, PERIPHERAL ARTERIOPATHIES AND CEREBROVASCULAR INSUFFICIENCIES | ZAMBON GROUP S.P.A. (IT) | 2000-06-27 | — | — | US | disclosed |
| US-5747513-A | HYPOTENSIVE AGENTS, HEART FAILURE AND CEREBROVASCULAR INSUFFICIENCY | ZAMBON GROUP, S.P.A. (IT) | 1998-05-05 | — | — | US | disclosed |
| EP-0719252-B1 | DERIVATIVES OF 2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALENE ACTIVE ON THE CARDIOVASCULAR SYSTEM | ZAMBON SPA (IT) | 1998-02-18 | — | — | EP | disclosed |