Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 17/20 | 0.59 |
| ▸ | MTOR | P42345 | 12/20 | 0.59 |
| ▸ | PIK3R1 | P27986 | 9/20 | 0.59 |
| ▸ | RICTOR | Q6R327 | 2/20 | 0.53 |
| ▸ | RPTOR | Q8N122 | 2/20 | 0.53 |
| ▸ | MAPKAP1 | Q9BPZ7 | 2/20 | 0.53 |
| ▸ | MLST8 | Q9BVC4 | 2/20 | 0.53 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | ATR | Q13535 | 1/20 | 0.42 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.42 |
| ▸ | AKT1 | P31749 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8062292 | 0.88 | PIK3CA (0.58) | PIK3CAMTORPIK3R1RICTORRPTOR | |
| SCHEMBL7952861 | 0.83 | PIK3CA (0.58) | PIK3CAMTORPIK3R1PIK3CDPIK3CG | |
| SCHEMBL12537215 | 0.80 | ATR (0.49) | PIK3CAMTORPIK3R1PIK3CGATR | |
| SCHEMBL30677407 | 0.78 | GAA (0.47) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL14249161 | 0.77 | PIK3CA (0.42) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL10327823 | 0.77 | PIK3CA (0.65) | PIK3CAMTORPIK3R1RICTORRPTOR | |
| SCHEMBL1568626 | 0.76 | PIK3CA (0.65) | PIK3CAMTORPIK3CG | |
| SCHEMBL14316117 | 0.76 | CNR2 (0.44) | PIK3CAMTORPIK3R1PIK3CDPIK3CG | |
| SCHEMBL31748485 | 0.75 | SRC (0.47) | PIK3CAMTORPIK3R1 | |
| SCHEMBL14249567 | 0.75 | PIK3CA (0.46) | PIK3CAMTORPIK3R1PIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009045174-A1 | 2-MORPHOLINYLPURINES AS INHIBITORS OF PI3K | S*BIO PTE LTD (SG) | 2009-04-09 | — | — | WO | disclosed |