Sugi Predict

Sugi Predict / Compounds / SCHEMBL806247

SCHEMBL806247

SCHEMBL806247

CCC(=O)c1c(O)cc(CC)oc1=O

nearest known ligand 0.55

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ ELANE P08246 5/20 0.55
▸ MEN1 O00255 2/20 0.52
▸ KMT2A Q03164 2/20 0.52
▸ CYP3A4 P08684 1/20 0.52
▸ PTGS1 P23219 1/20 0.52
▸ DRD3 P35462 1/20 0.52
▸ CA9 Q16790 3/20 0.43
▸ GAA P10253 2/20 0.40
▸ HMGCR P04035 1/20 0.38
▸ ALDH1A1 P00352 3/20 0.37
▸ SLC22A12 Q96S37 2/20 0.36
▸ HSP90AB1 P08238 1/20 0.36
▸ LMNA P02545 1/20 0.35
▸ L3MBTL1 Q9Y468 1/20 0.34
▸ TDP1 Q9NUW8 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16901805 0.87 ELANE (0.63) ELANEMEN1KMT2ACYP3A4PTGS1
SCHEMBL16901820 0.84 ELANE (0.49) ELANEMEN1KMT2ACYP3A4CA9
SCHEMBL10083172 0.82 ELANE (0.65) ELANEMEN1KMT2ACYP3A4PTGS1
SCHEMBL6026933 0.81 ELANE (0.68) ELANEMEN1KMT2ACYP3A4PTGS1
SCHEMBL10083170 0.79 ELANE (0.59) ELANEMEN1KMT2ACYP3A4PTGS1
SCHEMBL21274273 0.78 ELANE (0.57) ELANEMEN1KMT2ACYP3A4PTGS1
SCHEMBL11766413 0.76 ELANE (0.70) ELANEALDH1A1LMNATDP1
SCHEMBL21274268 0.75 ELANE (0.54) ELANEMEN1KMT2ACYP3A4PTGS1
SCHEMBL18626759 0.73 ELANE (0.48) ELANEMEN1KMT2ACYP3A4PTGS1
SCHEMBL15248152 0.73 ELANE (0.51) ELANEMEN1KMT2ACYP3A4PTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12371428-B2 Pyridone compounds and methods of use EXELIXIS, INC. (US) 2025-07-29 — — US disclosed
EP-3752143-B1 ANTIBACTERIAL AGENTS: O-ALKYL-DEUTERATED PYRONINS UNIV RUTGERS (US) 2025-04-09 — — EP disclosed
CN-112118837-B Antibacterial agent: o-alkyl deuterated pyronine 罗格斯新泽西州立大学 2024-07-09 — — CN disclosed
US-11685723-B2 Antibacterial agents: O-alkyl-deuterated pyronins RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) 2023-06-27 — — US disclosed
US-11685723-B2 Antibacterial agents: O-alkyl-deuterated pyronins RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) 2023-06-27 — — US disclosed
US-11685723-B2 Antibacterial agents: O-alkyl-deuterated pyronins RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) 2023-06-27 — — US disclosed
US-20220315579-A1 PYRIDONE COMPOUNDS AND METHODS OF USE EXELIXIS, INC. 2022-10-06 — — US disclosed
EP-4034532-A1 PYRIDONE COMPOUNDS AND METHODS OF USE IN THE MODULATION OF A PROTEIN KINASE Exelixis, Inc. (US) 2022-08-03 — — EP disclosed
CN-114787144-A Pyridone compounds and methods for modulating protein kinases 埃克塞里艾克西斯公司 2022-07-22 — — CN disclosed
WO-2021062245-A1 PYRIDONE COMPOUNDS AND METHODS OF USE IN THE MODULATION OF A PROTEIN KINASE EXELIXIS, INC. (US) 2021-04-01 — — WO disclosed
US-20130237595-A1 ANTIBACTERIAL AGENTS: HIGH-POTENCY MYXOPYRONIN DERIVATIVES RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY 2013-09-12 — — US disclosed
WO-2012037508-A2 ANTIBACTERIAL AGENTS: HIGH-POTENCY MYXOPYRONIN DERIVATIVES RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) 2012-03-22 — — WO disclosed
US-6228882-B1 MYXOPYRONINS AND CORALLOPYRONINS; RNA POLYMERASE INHIBITORS; SAPONIFICATION, ACIDIFICATION, AZIDING, ACYLATION ANADYS PHARMACEUTICALS, INC. 2001-05-08 — — US disclosed
US-6191288-B1 Pyronin antibacterials, process and novel intermediates thereto ANADYS PHARMACEUTICALS, INC. 2001-02-20 — — US disclosed
US-6184393-B1 MYXOPYRONINS AND CORALLOPYRONINS AS FURAN AND PYRAN- AND SMALL LACTONE-ANTIBIOTICS; INHIBITORS OF RNA POLYMERASE (RNAP) HAVING SELECTIVITY FOR HUMAN RNAP, CELL PENETRATION AND POTENCY AGAINST RIFAMPICIN-RESISTANT STAPH. AUREUS TRUSTEES OF BOSTON UNIVERSITY 2001-02-06 — — US disclosed
EP-1043990-A1 PYRONIN ANTIBACTERIALS, PROCESS AND NOVEL INTERMEDIATES THERETO Scriptgen Pharmaceuticals, Inc. (US) 2000-10-18 — — EP disclosed
WO-2000015626-A1 PROCESS FOR THE PREPARATION OF INTERMEDIATES FOR PYRONIN ANTIBACTERIALS ANADYS PHARMACEUTICALS, INC. (US) 2000-03-23 — — WO disclosed
US-6022983-A PREPARING A MYXOPYRONIN SCRIPTGEN PHARMACEUTICALS, INC. (US) 2000-02-08 — — US disclosed
WO-1999034793-A1 PYRONIN ANTIBACTERIALS, PROCESS AND NOVEL INTERMEDIATES THERETO SCRIPTGEN PHARMACEUTICALS, INC. (US) 1999-07-15 — — WO disclosed
US-4745116-A INHIBITORS OF SERINE PROTEASE SYNTEX (U.S.A.) INC. (US) 1988-05-17 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12371428-B2 Pyridone compounds and methods of use PDXK, PLK2, MAP4K2 ELANE 3429/4885MEN1 3040/4885KMT2A 3773/4885
US-11685723-B2 Antibacterial agents: O-alkyl-deuterated pyronins POLN, POLI, POLRMT ELANE 1287/4885MEN1 2552/4885KMT2A 2267/4885
US-20220315579-A1 PYRIDONE COMPOUNDS AND METHODS OF USE PDXK, PLK2, MAP4K2 ELANE 3429/4885MEN1 3040/4885KMT2A 3773/4885
US-20130237595-A1 ANTIBACTERIAL AGENTS: HIGH-POTENCY MYXOPYRONIN DERIVATIVES YBX1, POLRMT, YBX3 ELANE 2782/4885MEN1 2933/4885KMT2A 2097/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.