Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 4/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 9/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CDC7 | O00311 | 4/20 | 0.40 |
| ▸ | DBF4 | Q9UBU7 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL788778 | 0.74 | PIK3CD (1.00) | PIK3CDALDH1A1HSD17B10RXFP1PIK3CG | |
| SCHEMBL1703918 | 0.62 | PIK3CD (0.58) | PIK3CDALDH1A1HSD17B10RXFP1PIK3CG | |
| SCHEMBL16004753 | 0.59 | PIK3CG (1.00) | PIK3CDALDH1A1HSD17B10RXFP1PIK3CG | |
| SCHEMBL10426489 | 0.59 | G6PD (0.64) | ALDH1A1HSD17B10CDC7DBF4TSHR | |
| SCHEMBL31439407 | 0.57 | PAK1 (0.71) | ALDH1A1HSD17B10CDC7DBF4TSHR | |
| SCHEMBL2115555 | 0.57 | PAK1 (0.71) | ALDH1A1HSD17B10CDC7DBF4TSHR | |
| SCHEMBL29851680 | 0.57 | CDC7 (1.00) | ALDH1A1HSD17B10CDC7DBF4 | |
| SCHEMBL2120065 | 0.57 | CDC7 (1.00) | ALDH1A1HSD17B10CDC7DBF4 | |
| SCHEMBL3396404 | 0.57 | TSHR (0.78) | ALDH1A1POLBRECQLGAASMN1; SMN2 | |
| SCHEMBL10435363 | 0.56 | CYP1A2 (1.00) | ALDH1A1HSD17B10CDC7DBF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012037204-A1 | INHIBITORS OF PI3K-DELTA AND METHODS OF THEIR USE AND MANUFACTURE | EXELIXIS, INC. (US) | 2012-03-22 | — | — | WO | disclosed |