Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.50 |
| ▸ | KDM1A | O60341 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.44 |
| ▸ | SMYD3 | Q9H7B4 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4175744 | 0.90 | RAB9A (0.53) | HDAC6HDAC4HDAC1HDAC8HDAC3 | |
| Hydrochloric Acid SCHEMBL9409383 | 0.81 | NPC1 (0.48) | HDAC6HDAC4HDAC1HDAC8HDAC3 | |
| Hydrochloric Acid SCHEMBL9409437 | 0.78 | DGAT1 (0.49) | HDAC6HDAC4HDAC1HDAC8HDAC3 | |
| Hydrochloric Acid SCHEMBL9409621 | 0.78 | P2RY14 (0.42) | HDAC6HDAC4HDAC1HDAC8HDAC3 | |
| SCHEMBL5497348 | 0.77 | RAB9A (0.56) | NAMPTKDM1AHDAC6HDAC4KDM4E | |
| SCHEMBL15088518 | 0.77 | NAMPT (0.54) | NAMPTKDM1AHDAC6HDAC4KDM4E | |
| SCHEMBL9409598 | 0.77 | DGAT1 (0.47) | HDAC6HDAC4HDAC1HDAC8HDAC3 | |
| Hydrochloric Acid SCHEMBL9409405 | 0.76 | DGAT1 (0.46) | HDAC6HDAC4HDAC1HDAC8HDAC3 | |
| Hydrochloric Acid SCHEMBL9409460 | 0.76 | DGAT1 (0.46) | HDAC6HDAC4HDAC1HDAC8HDAC3 | |
| SCHEMBL4179238 | 0.76 | HDAC8 (0.51) | HDAC6HDAC1HDAC8HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2610258-A1 | Substituted piperidino dihydrothieno pyrimidines | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-07-03 | — | — | EP | disclosed |
| EP-2380891-A1 | Substituted piperidino-dihydrothienopyrimidines | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-10-26 | — | — | EP | disclosed |
| WO-2009050248-A1 | SUBSTITUTED PIPERIDINO-DIHYDROTHIENOPYRIMIDINES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-04-23 | — | — | WO | disclosed |