Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18177907 | 0.98 | ALDH1A1 (0.63) | ALDH1A1SMN1; SMN2SIGMAR1TDP1L3MBTL1 | |
| SCHEMBL8059112 | 0.85 | SIGMAR1 (0.50) | ALDH1A1SMN1; SMN2SIGMAR1GAAMEN1 | |
| SCHEMBL8059039 | 0.84 | SMN1; SMN2 (0.66) | ALDH1A1SMN1; SMN2SIGMAR1MEN1KMT2A | |
| SCHEMBL2928831 | 0.79 | ALDH1A1 (0.63) | ALDH1A1SMN1; SMN2TDP1L3MBTL1GAA | |
| SCHEMBL19958938 | 0.79 | SIGMAR1 (0.43) | ALDH1A1SMN1; SMN2SIGMAR1TDP1 | |
| SCHEMBL8023138 | 0.78 | ALDH1A1 (0.67) | ALDH1A1SMN1; SMN2SIGMAR1TDP1L3MBTL1 | |
| SCHEMBL10101745 | 0.76 | ALDH1A1 (0.71) | ALDH1A1SMN1; SMN2SIGMAR1TDP1GAA | |
| SCHEMBL2924557 | 0.76 | ALDH1A1 (0.70) | ALDH1A1SMN1; SMN2TDP1L3MBTL1GAA | |
| SCHEMBL12376549 | 0.75 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2SIGMAR1TDP1L3MBTL1 | |
| SCHEMBL24926262 | 0.74 | ALDH1A1 (0.74) | ALDH1A1SMN1; SMN2SIGMAR1TDP1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009042607-A1 | THIAZOLOPYRIMIDINE P13K INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2009-04-02 | — | — | WO | disclosed |
| WO-2008063202-A2 | HETEROBICYCLIC THIOPHENE COMPOUNDS FOR THE TREATMENT OF CANCER | ARRAY BIOPHARMA INC. (US) | 2008-05-29 | — | — | WO | disclosed |