Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | PTGER1 | P34995 | 9/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CCR5 | P51681 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7816794 | 0.89 | KMT2A (0.41) | MEN1KMT2AHTTMAPK1GAA | |
| SCHEMBL8067458 | 0.89 | PTGER1 (0.38) | MEN1KMT2APTGER1CYP1A2CCR5 | |
| SCHEMBL8067463 | 0.89 | PTGER1 (0.38) | MEN1KMT2APTGER1CYP1A2CCR5 | |
| SCHEMBL7813525 | 0.88 | GAA (0.49) | MEN1KMT2AGAATSHRALDH1A1 | |
| SCHEMBL7662551 | 0.87 | HPGD (0.42) | MEN1KMT2AHTTHPGDPTGER1 | |
| SCHEMBL1901395 | 0.86 | PTGDR2 (0.40) | MEN1KMT2AHTTALDH1A1HPGD | |
| SCHEMBL7666905 | 0.86 | LMNA (0.43) | MEN1KMT2AHTTGAAALDH1A1 | |
| SCHEMBL7816791 | 0.85 | MEN1 (0.43) | MEN1KMT2AHTTMAPK1GAA | |
| SCHEMBL7816753 | 0.85 | PTGDR2 (0.40) | MEN1KMT2AHTTTSHRPTGER1 | |
| SCHEMBL7670592 | 0.85 | ALDH1A1 (0.43) | MEN1KMT2AALDH1A1PTGER1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6100258-A | 6-(N-(5-BROMO-2-(2-METHYLPROP-2-EN-1-YLOXY)BENZYL)-N -ETHYLAMINO)-PYRIDAZIN-3-YLCARBOXYLIC ACID, AND OTHER 3,6-DISUBSTITUTED PYRIDAZINE DERIVATIVES OF SPECIFIED FORMULA; RELIEVING PAIN | ZENECA LIMITED (GB) | 2000-08-08 | — | — | US | claimed |