Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.49 |
| ▸ | DHODH | Q02127 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 6/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MITF | O75030 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CRACR2A | Q9BSW2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8063449 | 0.80 | DHODH (0.73) | DHODHNPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL9564642 | 0.80 | RAB9A (0.62) | DHODHMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8061153 | 0.79 | DHODH (0.74) | DHODHNPC1RAB9ASMN1; SMN2HTT | |
| SCHEMBL8808712 | 0.79 | MAPT (0.52) | DHODHMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8813080 | 0.77 | MAPT (0.49) | DHODHMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8493690 | 0.75 | KMT2A (0.49) | MAPTNPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL8045714 | 0.75 | RAB9A (0.47) | DHODHMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8057748 | 0.74 | RAB9A (0.53) | DHODHMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8045733 | 0.72 | CRACR2A (0.51) | DHODHNPC1RAB9ASMN1; SMN2HTT | |
| SCHEMBL8493536 | 0.71 | LMNA (0.36) | NPC1RAB9ASMN1; SMN2POLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5476866-A | Antiinflammatory agents | ROUSSEL UCLAF (FR) | 1995-12-19 | — | — | US | claimed |
| EP-0646578-A1 | Phenyl carboxamide-isoxazole-derivatives and salts, process for their preparation, their use as pharmaceuticals, and pharmaceutical compositions containing them | ROUSSEL UCLAF (FR) | 1995-04-05 | — | — | EP | claimed |
| US-5506249-A | ANTIINFLAMMATORY, ANTIPROLIFERATIVE AND ANTITUMOR ACTIVITY | ROUSSEL UCLAF (FR) | 1996-04-09 | — | — | US | disclosed |
| US-5476866-A | Antiinflammatory agents | ROUSSEL UCLAF (FR) | 1995-12-19 | — | — | US | disclosed |
| EP-0646578-A1 | Phenyl carboxamide-isoxazole-derivatives and salts, process for their preparation, their use as pharmaceuticals, and pharmaceutical compositions containing them | ROUSSEL UCLAF (FR) | 1995-04-05 | — | — | EP | disclosed |