SCHEMBL806381

SCHEMBL806381

O=Cc1ccc(N(c2ccc(C=O)cc2)c2ccc(C=Cc3ccc(N(c4ccc(C=O)cc4)c4ccc(C=O)cc4)cc3)cc2)cc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.58
ALDH3A1 P30838 1/20 0.58
ALDH1A3 P47895 1/20 0.58
CYP2A6 P11509 4/20 0.56
CYP2A13 Q16696 1/20 0.56
KDM4E B2RXH2 1/20 0.44
HSD17B10 Q99714 1/20 0.44
ALDH5A1 P51649 1/20 0.44
ABAT P80404 1/20 0.44
RELA Q04206 1/20 0.41
APP P05067 4/20 0.40
MEN1 O00255 2/20 0.40
MAPT P10636 2/20 0.40
KMT2A Q03164 2/20 0.40
LMNA P02545 1/20 0.40
TYR P14679 1/20 0.39
NPC1 O15118 1/20 0.39
ALOX15 P16050 1/20 0.39
CASP1 P29466 1/20 0.39
RAB9A P51151 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19313178 1.00 ALDH1A1 (0.58) ALDH1A1ALDH3A1ALDH1A3CYP2A6CYP2A13
SCHEMBL3181867 1.00 ALDH1A1 (0.58) ALDH1A1ALDH3A1ALDH1A3CYP2A6CYP2A13
SCHEMBL3181855 1.00 ALDH1A1 (0.58) ALDH1A1ALDH3A1ALDH1A3CYP2A6CYP2A13
SCHEMBL29258833 0.92 ALDH1A1 (0.65) ALDH1A1ALDH3A1ALDH1A3CYP2A6CYP2A13
SCHEMBL309261 0.92 ALDH1A1 (0.65) ALDH1A1ALDH3A1ALDH1A3CYP2A6CYP2A13
SCHEMBL4769486 0.91 ALDH1A1 (0.52) ALDH1A1ALDH3A1ALDH1A3CYP2A6CYP2A13
SCHEMBL4769478 0.91 ALDH1A1 (0.52) ALDH1A1ALDH3A1ALDH1A3CYP2A6CYP2A13
SCHEMBL4242047 0.89 ALDH1A1 (0.56) ALDH1A1ALDH3A1ALDH1A3CYP2A6CYP2A13
SCHEMBL7686419 0.89 CYP2A6 (0.64) ALDH1A1ALDH3A1ALDH1A3CYP2A6CYP2A13
SCHEMBL13777816 0.89 CYP2A6 (0.64) ALDH1A1ALDH3A1ALDH1A3CYP2A6CYP2A13

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2616883-B1 ELECTROPHOTOGRAPHIC PHOTOCONDUCTOR, IMAGE FORMING METHOD, IMAGE FORMING APPARATUS, AND PROCESS CARTRIDGE RICOH CO LTD (JP) 2017-09-06 EP disclosed
US-8871412-B2 Electrophotographic photoconductor, image forming method, image forming apparatus, and process cartridge RICOH COMPANY, LTD. (JP) 2014-10-28 US disclosed
US-20130177842-A1 ELECTROPHOTOGRAPHIC PHOTOCONDUCTOR, IMAGE FORMING METHOD, IMAGE FORMING APPARATUS, AND PROCESS CARTRIDGE RICOH COMPANY, LTD. (JP) 2013-07-11 US disclosed
WO-2012036295-A1 ELECTROPHOTOGRAPHIC PHOTOCONDUCTOR, IMAGE FORMING METHOD, IMAGE FORMING APPARATUS, AND PROCESS CARTRIDGE RICOH COMPANY, LTD. (JP) 2012-03-22 WO disclosed
US-20120021346-A1 IMAGE BEARING MEMBER AND IMAGE FORMING METHOD, IMAGE FORMING APPARATUS, AND PROCESS CARTRIDGE USING SAME RICOH COMPANY, LTD. (JP) 2012-01-26 US disclosed
US-20110200926-A1 ELECTROPHOTOGRAPHIC PHOTOCONDUCTOR, IMAGE FORMING METHOD, IMAGE FORMING APPARATUS, AND PROCESS CARTRIDGE RICOH COMPANY, LTD. (JP) 2011-08-18 US disclosed
US-20110081607-A1 METHYLOL COMPOUND, ALDEHYDE COMPOUND, METHOD FOR PREPARING THE METHYLOL COMPOUND USING THE ALDEHYDE COMPOUND, AND PHOTORECEPTOR USING THE METHYLOL COMPOUND RICOH COMPANY, LTD., (JP) 2011-04-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110081607-A1 METHYLOL COMPOUND, ALDEHYDE COMPOUND, METHOD FOR PREPARING THE METHYLOL COMPOUND USING THE ALDEHYDE COMPOUND, AND PHOTORECEPTOR USING THE METHYLOL COMPOUND ALDH1A2, MGMT, MCOLN2 ALDH1A1 98/4885ALDH3A1 124/4885ALDH1A3 12/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.