Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 4/20 | 0.46 |
| ▸ | MMP12 | P39900 | 4/20 | 0.46 |
| ▸ | MMP8 | P22894 | 3/20 | 0.46 |
| ▸ | MMP13 | P45452 | 3/20 | 0.46 |
| ▸ | MMP14 | P50281 | 3/20 | 0.46 |
| ▸ | MMP16 | P51512 | 3/20 | 0.46 |
| ▸ | MMP9 | P14780 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MMP1 | P03956 | 1/20 | 0.44 |
| ▸ | MMP3 | P08254 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | PPARD | Q03181 | 1/20 | 0.42 |
| ▸ | F10 | P00742 | 1/20 | 0.42 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8061466 | 0.86 | PTGS2 (0.47) | ALDH1A1SMN1; SMN2PTGS2PTGS1NR1H4 | |
| SCHEMBL8046688 | 0.84 | CXCL8 (0.49) | MMP2MMP12MMP13MMP14MMP9 | |
| SCHEMBL7604656 | 0.81 | NR1H4 (0.45) | NPC1PPARDRAB9ASMN1; SMN2PTGS2 | |
| SCHEMBL8057238 | 0.81 | CXCL8 (0.43) | ALDH1A1MAPTSMN1; SMN2PTGS2PTGS1 | |
| SCHEMBL8061558 | 0.78 | PTGS2 (0.47) | NPC1FFAR1RAB9ATP53PTGS2 | |
| SCHEMBL8046473 | 0.77 | CXCL8 (0.44) | POLBPTGS2PTGS1NR1H4 | |
| SCHEMBL8064201 | 0.77 | MMP2 (0.47) | MMP2MMP12MMP8MMP13MMP14 | |
| SCHEMBL8059092 | 0.76 | NAPRT (0.51) | ALDH1A1NPC1RAB9ASMN1; SMN2USP2 | |
| SCHEMBL8061440 | 0.76 | CXCL8 (0.58) | RAB9APTGS2PTGS1NR1H4 | |
| SCHEMBL7166224 | 0.75 | MAPT (0.59) | MMP2MMP12MMP8MMP13MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6046180-A | NAALADase inhibitors | GUILFORD PHARMACEUTICALS INC. (US) | 2000-04-04 | — | — | US | disclosed |
| EP-0936914-A4 | — | — | 1999-08-25 | — | — | EP | disclosed |
| EP-0936914-A1 | HYDROXY-PHOSPHINYL DERIVATIVES USEFUL AS NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1999-08-25 | — | — | EP | disclosed |
| WO-1997048400-A1 | HYDROXY-PHOSPHINYL DERIVATIVES USEFUL AS NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1997-12-24 | — | — | WO | disclosed |