Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.34 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.34 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.34 |
| ▸ | FPR2 | P25090 | 1/20 | 0.34 |
| ▸ | PPARD | Q03181 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5889359 | 0.81 | TAS1R3 (0.43) | CYP1A2CYP2C9CYP2C19ATMLMNA | |
| SCHEMBL5352189 | 0.81 | TAS1R3 (0.43) | CYP1A2CYP2C9CYP2C19ATMLMNA | |
| SCHEMBL5889331 | 0.81 | TAS1R3 (0.43) | CYP1A2CYP2C9CYP2C19ATMLMNA | |
| SCHEMBL7830420 | 0.81 | LDHA (0.50) | CYP1A2CYP2C9CYP2C19ATMALDH1A1 | |
| SCHEMBL7834588 | 0.81 | LDHA (0.50) | CYP1A2CYP2C9CYP2C19ATMALDH1A1 | |
| SCHEMBL6951996 | 0.76 | ACE (0.41) | FOLH1 | |
| SCHEMBL6951990 | 0.76 | ACE (0.41) | FOLH1 | |
| SCHEMBL5889370 | 0.74 | HTT (0.50) | CYP1A2CYP2C9CYP2C19LMNAALDH1A1 | |
| SCHEMBL5355623 | 0.74 | HTT (0.50) | CYP1A2CYP2C9CYP2C19LMNAALDH1A1 | |
| SCHEMBL5351455 | 0.74 | HTT (0.50) | CYP1A2CYP2C9CYP2C19LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1017667-A1 | 2-Amino-6-methyl-7-acetyl-tetraline and pharmaceutical compositions for the prevention and therapeutic treatment of inflammatory and/or autoimmune pathologies | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) | 2000-07-12 | — | — | EP | disclosed |
| WO-1999015494-A1 | 2-AMINOTETRALINES, A PROCESS FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS, FOR THE PREVENTION AND THERAPEUTIC TREATMENT OF INFLAMMATORY AND/OR AUTOIMMUNE PATHOLOGIES | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 1999-04-01 | — | — | WO | disclosed |