Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.48 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.48 |
| ▸ | PRSS1 | P07477 | 10/20 | 0.43 |
| ▸ | TMPRSS15 | P98073 | 10/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5351455 | 1.00 | HTT (0.50) | HTTLMNAMAPK1RAB9ATAS1R3 | |
| SCHEMBL5355623 | 1.00 | HTT (0.50) | HTTLMNAMAPK1RAB9ATAS1R3 | |
| SCHEMBL7821313 | 0.91 | CYP1A2 (0.48) | LMNAMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL7821304 | 0.91 | CYP1A2 (0.48) | LMNAMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL7912394 | 0.87 | TAS1R3 (0.47) | HTTLMNARAB9ATAS1R3TAS1R1 | |
| SCHEMBL7899441 | 0.87 | TAS1R3 (0.47) | HTTLMNARAB9ATAS1R3TAS1R1 | |
| SCHEMBL7908375 | 0.85 | CES2 (0.40) | MAPK1RAB9APRSS1TMPRSS15MAPT | |
| SCHEMBL7899386 | 0.85 | CES2 (0.40) | MAPK1RAB9APRSS1TMPRSS15MAPT | |
| SCHEMBL7908401 | 0.85 | CES2 (0.40) | MAPK1RAB9APRSS1TMPRSS15MAPT | |
| SCHEMBL5889359 | 0.79 | TAS1R3 (0.43) | HTTLMNAMAPK1RAB9ATAS1R3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7041703-B2 | 2-aminotetralines and pharmaceutical compositions for the prevention and therapeutic treatment of inflammatory and/or autoimmune pathologies | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2006-05-09 | — | — | US | disclosed |
| US-6849663-B2 | 2-Aminotetralines, a process for their preparation, and pharmaceutical compositions, for the prevention and therapeutic treatment of inflammatory and/or autoimmune pathologies | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2005-02-01 | — | — | US | disclosed |
| US-20030229148-A1 | 2-aminotetralines, a process for their preparation, and pharmaceutical compositions, for the prevention and therapeutic treatment of inflammatory and/or autoimmune pathologies | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. | 2003-12-11 | — | — | US | disclosed |
| EP-1017667-B1 | 2-Amino-6-methyl-7-acetyl-tetraline and pharmaceutical compositions for the prevention and therapeutic treatment of inflammatory and/or autoimmune pathologies | SIGMA TAU IND FARMACEUTI (IT) | 2003-11-19 | — | — | EP | disclosed |
| US-20030158266-A1 | 2-aminotetralines, a process for their preparation, and pharmaceutical compositions, for the prevention and therapeutic treatment of inflammatory and/or autoimmune pathologies | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. | 2003-08-21 | — | — | US | disclosed |
| US-20020123652-A1 | 2-AMINOTETRALINES AND PHARMACEUTICAL COMPOSITIONS FOR THE PREVENTION AND THERAPEUTIC TREATMENT OF INFLAMMATORY AND/OR AUTOIMMUNE PATHOLOGIES | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A (IT) | 2002-09-05 | — | — | US | disclosed |
| US-6207709-B1 | FOR THERAPY AND PROPHYLAXIS OF NEURODEGENERATIVE DISEASES, SUCH AS HUNTINGTON'S CHOREA, ALZHEIMER'S DISEASE, DEMENTIA CAUSED BY AQUIRED IMMUNODEFICIENCY SYNDROME (AIDS), INFARCTUAL DEMENTIA, CEREBRAL ISCHEMIA, CEREBRAL HYPOXIA, EPILEPSY | PHARMACIA & UPJOHN S.P.A. (IT) | 2001-03-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020123652-A1 | 2-AMINOTETRALINES AND PHARMACEUTICAL COMPOSITIONS FOR THE PREVENTION AND THERAPEUTIC TREATMENT OF INFLAMMATORY AND/OR AUTOIMMUNE PATHOLOGIES | AADAT, IL2, TPMT | HTT 1541/4885LMNA 2606/4885MAPK1 3526/4885 |
| US-20030229148-A1 | 2-aminotetralines, a process for their preparation, and pharmaceutical compositions, for the prevention and therapeutic treatment of inflammatory and/or autoimmune pathologies | AADAT, IL2, TPMT | HTT 1280/4885LMNA 2373/4885MAPK1 3177/4885 |
| US-20030158266-A1 | 2-aminotetralines, a process for their preparation, and pharmaceutical compositions, for the prevention and therapeutic treatment of inflammatory and/or autoimmune pathologies | AADAT, IL2, TPMT | HTT 1280/4885LMNA 2373/4885MAPK1 3177/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.