Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 8/20 | 0.53 |
| ▸ | DCTPP1 | Q9H773 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | FAAH | O00519 | 2/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.45 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8061058 | 0.82 | HSD11B1 (0.49) | HSD11B1 | |
| SCHEMBL5247343 | 0.81 | HSD11B1 (0.70) | HSD11B1EPHX2LMNABDKRB2BDKRB1 | |
| SCHEMBL4542938 | 0.81 | HSD11B1 (0.51) | HSD11B1DCTPP1ALDH1A1EPHX2FAAH | |
| SCHEMBL4542937 | 0.80 | EPHX2 (0.57) | HSD11B1EPHX2 | |
| SCHEMBL8049830 | 0.78 | HSD11B1 (0.49) | HSD11B1 | |
| SCHEMBL4306300 | 0.77 | HSD11B1 (0.69) | HSD11B1ALDH1A1EPHX2LMNABDKRB2 | |
| SCHEMBL4531620 | 0.75 | HSD11B1 (0.58) | HSD11B1DCTPP1ALDH1A1EPHX2 | |
| SCHEMBL1299167 | 0.74 | TSHR (0.68) | HSD11B1ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL21512378 | 0.73 | HSD11B1 (0.49) | HSD11B1DCTPP1ALDH1A1FAAHHDAC3 | |
| SCHEMBL21511373 | 0.73 | HSD11B1 (0.49) | HSD11B1DCTPP1ALDH1A1FAAHHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |