Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 9/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.46 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4537246 | 0.92 | HSD11B1 (0.56) | HSD11B1TP53EPHX2DCTPP1 | |
| SCHEMBL4533514 | 0.87 | ALDH1A1 (0.53) | ALDH1A1L3MBTL1EPHX2FAAHEPHX1 | |
| SCHEMBL4541794 | 0.86 | HSD11B1 (0.54) | HSD11B1TP53 | |
| SCHEMBL4537189 | 0.85 | FAAH (0.49) | HSD11B1TP53ALDH1A1L3MBTL1EPHX2 | |
| SCHEMBL4539833 | 0.85 | HSD11B1 (0.53) | HSD11B1TP53 | |
| SCHEMBL4539885 | 0.82 | FAAH (0.45) | HSD11B1TP53ALDH1A1L3MBTL1EPHX2 | |
| SCHEMBL4539565 | 0.81 | EPHX2 (0.48) | TP53ALDH1A1L3MBTL1EPHX2FAAH | |
| SCHEMBL8064757 | 0.81 | HSD11B1 (0.53) | HSD11B1ALDH1A1L3MBTL1EPHX2FAAH | |
| SCHEMBL4538175 | 0.81 | ALDH1A1 (0.57) | TP53ALDH1A1L3MBTL1EPHX2LMNA | |
| SCHEMBL4539894 | 0.81 | ALDH1A1 (0.57) | ALDH1A1L3MBTL1LMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |