Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | BRD2 | P25440 | 1/20 | 0.38 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.38 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8055946 | 0.88 | PDE4D (0.55) | PDE4DMAPK10CHRM3ALDH1A1MAPT | |
| SCHEMBL15906145 | 0.87 | MAPT (0.46) | PDE4DMAPK10CHRM3MAPTTP53 | |
| SCHEMBL8064779 | 0.87 | PDE4D (0.42) | PDE4DMAPK10CHRM3PDE4BMKNK1 | |
| SCHEMBL8055203 | 0.85 | PDE4D (0.44) | PDE4DCHRM3ALDH1A1MAPTPDE4B | |
| SCHEMBL4322258 | 0.83 | ACHE (0.44) | PDE4DMAPK10ALDH1A1MAPTLMNA | |
| SCHEMBL8062936 | 0.83 | L3MBTL1 (0.39) | PDE4DCHRM3ALDH1A1MAPTPDE4B | |
| SCHEMBL7913026 | 0.82 | PDE4B (0.43) | PDE4DPDE4BFAAH | |
| SCHEMBL8066491 | 0.80 | PDE4D (0.41) | PDE4DCHRM3PDE4B | |
| SCHEMBL8066667 | 0.80 | PDE4D (0.42) | PDE4DPDE4B | |
| SCHEMBL8066487 | 0.79 | PDE4D (0.41) | PDE4DCHRM3MAPTTP53LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009067600-A2 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | WO | disclosed |