Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 5/20 | 0.48 |
| ▸ | DRD2 | P14416 | 5/20 | 0.48 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | HTR1D | P28221 | 2/20 | 0.43 |
| ▸ | HTR1B | P28222 | 2/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6816368 | 0.86 | DRD2 (0.50) | DRD4DRD2MTNR1AMTNR1BDRD3 | |
| SCHEMBL7246466 | 0.86 | DRD2 (0.50) | DRD4DRD2MTNR1AMTNR1BDRD3 | |
| SCHEMBL6816380 | 0.86 | DRD2 (0.50) | DRD4DRD2MTNR1AMTNR1BDRD3 | |
| SCHEMBL7482232 | 0.85 | DRD4 (0.48) | DRD4DRD2MTNR1AMTNR1BDRD3 | |
| SCHEMBL6820059 | 0.83 | MTNR1A (0.47) | DRD4DRD2MTNR1AMTNR1BDRD3 | |
| SCHEMBL6820035 | 0.83 | MTNR1A (0.47) | DRD4DRD2MTNR1AMTNR1BDRD3 | |
| SCHEMBL6816677 | 0.77 | SMN1; SMN2 (0.42) | GAASMN1; SMN2 | |
| SCHEMBL8075560 | 0.77 | KCNH2 (0.61) | DRD2MTNR1AMTNR1BDRD3SMN1; SMN2 | |
| SCHEMBL7236226 | 0.77 | USP30 (0.44) | DRD2DRD3HTR1BKMT2AHTR2A | |
| SCHEMBL7236221 | 0.77 | USP30 (0.44) | DRD2DRD3HTR1BKMT2AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1000048-A1 | SUBSTITUTED 1,2,3,4-TETRAHYDRONAPHTHALENE DERIVATIVES | Astra Aktiebolag (SE) | 2000-05-17 | — | — | EP | disclosed |
| WO-1999005134-A1 | SUBSTITUTED 1,2,3,4-TETRAHYDRONAPHTHALENE DERIVATIVES | ASTRA AKTIEBOLAG (SE) | 1999-02-04 | — | — | WO | disclosed |