Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H3 | Q13133 | 2/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KLK7 | P49862 | 2/20 | 0.32 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.32 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.32 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.30 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.30 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8073190 | 0.84 | NR1H3 (0.36) | NR1H3NR1H2KLK7KLK5PLA2G10 | |
| SCHEMBL8886431 | 0.84 | NR1H3 (0.36) | NR1H3NR1H2KLK7KLK5PLA2G10 | |
| SCHEMBL8073393 | 0.80 | NR1H3 (0.34) | NR1H3NR1H2KLK7KLK5PLA2G10 | |
| SCHEMBL8065492 | 0.80 | NR1H3 (0.34) | NR1H3NR1H2KLK7KLK5PLA2G10 | |
| SCHEMBL8885982 | 0.80 | NR1H3 (0.34) | NR1H3NR1H2KLK7KLK5PLA2G10 | |
| SCHEMBL8886010 | 0.77 | KLK7 (0.48) | NR1H3NR1H2KLK7KLK5PLA2G10 | |
| SCHEMBL8078090 | 0.77 | KLK7 (0.39) | NR1H3NR1H2KLK7KLK5GPR119 | |
| SCHEMBL5891618 | 0.77 | KLK7 (0.48) | NR1H3NR1H2KLK7KLK5PLA2G10 | |
| SCHEMBL8884829 | 0.77 | KLK7 (0.48) | NR1H3NR1H2KLK7KLK5PLA2G10 | |
| SCHEMBL8886176 | 0.77 | GLA (0.39) | NR1H3NR1H2KLK7KLK5PLA2G10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0666844-B1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2000-08-23 | — | — | EP | disclosed |
| US-5470832-A | Inhibitors of geranylgeranyl-protein transferase | MERCK & CO., INC. (US) | 1995-11-28 | — | — | US | disclosed |
| EP-0666844-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO. INC. (US) | 1995-08-16 | — | — | EP | disclosed |
| WO-1994010138-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1994-05-11 | — | — | WO | disclosed |