Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H3 | Q13133 | 2/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | KLK7 | P49862 | 2/20 | 0.31 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.30 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.30 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8885982 | 0.85 | NR1H3 (0.34) | NR1H3NR1H2KLK7KLK5PLA2G10 | |
| SCHEMBL8065492 | 0.85 | NR1H3 (0.34) | NR1H3NR1H2KLK7KLK5PLA2G10 | |
| SCHEMBL8073190 | 0.81 | NR1H3 (0.36) | NR1H3NR1H2KLK7KLK5PLA2G10 | |
| SCHEMBL8886431 | 0.81 | NR1H3 (0.36) | NR1H3NR1H2KLK7KLK5PLA2G10 | |
| SCHEMBL8886010 | 0.80 | KLK7 (0.48) | NR1H3NR1H2KLK7KLK5PLA2G10 | |
| SCHEMBL5891618 | 0.80 | KLK7 (0.48) | NR1H3NR1H2KLK7KLK5PLA2G10 | |
| SCHEMBL8884829 | 0.80 | KLK7 (0.48) | NR1H3NR1H2KLK7KLK5PLA2G10 | |
| SCHEMBL8065148 | 0.80 | NR1H3 (0.36) | NR1H3NR1H2KLK7KLK5PLA2G10 | |
| SCHEMBL8078090 | 0.74 | KLK7 (0.39) | NR1H3NR1H2KLK7KLK5 | |
| SCHEMBL8886176 | 0.73 | GLA (0.39) | NR1H3NR1H2KLK7KLK5PLA2G10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0666844-B1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2000-08-23 | — | — | EP | disclosed |
| WO-1994010138-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1994-05-11 | — | — | WO | disclosed |