Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK7 | P49862 | 7/20 | 0.39 |
| ▸ | KLK5 | Q9Y337 | 5/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.36 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.36 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TACR1 | P25103 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8886431 | 0.85 | NR1H3 (0.36) | KLK7KLK5NR1H3NR1H2GPR119 | |
| SCHEMBL8073190 | 0.85 | NR1H3 (0.36) | KLK7KLK5NR1H3NR1H2GPR119 | |
| SCHEMBL8884829 | 0.82 | KLK7 (0.48) | KLK7KLK5NR1H3NR1H2GPR119 | |
| SCHEMBL5891618 | 0.82 | KLK7 (0.48) | KLK7KLK5NR1H3NR1H2GPR119 | |
| SCHEMBL8886010 | 0.82 | KLK7 (0.48) | KLK7KLK5NR1H3NR1H2GPR119 | |
| SCHEMBL8065148 | 0.77 | NR1H3 (0.36) | KLK7KLK5NR1H3NR1H2GPR119 | |
| SCHEMBL8065492 | 0.74 | NR1H3 (0.34) | KLK7KLK5NR1H3NR1H2 | |
| SCHEMBL8073393 | 0.74 | NR1H3 (0.34) | KLK7KLK5NR1H3NR1H2 | |
| SCHEMBL8885982 | 0.74 | NR1H3 (0.34) | KLK7KLK5NR1H3NR1H2 | |
| SCHEMBL8065802 | 0.73 | KLK7 (0.42) | KLK7KLK5NR1H3NR1H2GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0666844-B1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2000-08-23 | — | — | EP | disclosed |
| WO-1994010138-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1994-05-11 | — | — | WO | disclosed |