SCHEMBL8065165

CC[C@H](C)C(CS(=O)(=O)C(C)(Cc1ccccc1)C(=O)N[C@@H]1CCOC1=O)NCC(CSC(c1ccccc1)(c1ccccc1)c1ccccc1)NC(=O)OC(C)(C)C

nearest known ligand 0.33

Predicted protein targets (top 9)

	gene	UniProt	supporting neighbours	confidence
▸	KMT2A	Q03164	2/20	0.32

▸	SYK	P43405	1/20	0.32

▸	SCN9A	Q15858	3/20	0.32

▸	ADORA1	P30542	1/20	0.32

▸	ATM	Q13315	1/20	0.32

▸	REN	P00797	4/20	0.31

▸	MEN1	O00255	1/20	0.31

▸	CYP1A2	P05177	1/20	0.31

▸	CA2	P00918	1/20	0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL8065171	0.88	SYK (0.35)	KMT2ASYKSCN9AADORA1ATM
SCHEMBL8065509	0.87	KMT2A (0.33)	KMT2ASYKSCN9AADORA1ATM
SCHEMBL8073492	0.86	KMT2A (0.38)	KMT2ASCN9AATMRENMEN1
SCHEMBL8079882	0.82	FNTA (0.39)	KMT2ASCN9AATMREN
SCHEMBL5891423	0.82	FNTA (0.39)	KMT2ASCN9AATMREN
SCHEMBL8075177	0.82	KDM4E (0.34)	SCN9AADORA1REN
SCHEMBL8075650	0.80	CTRB1 (0.34)	SCN9AADORA1REN
SCHEMBL8075466	0.80	SCN9A (0.33)	SCN9AADORA1REN
SCHEMBL8961398	0.80	SCN9A (0.45)	KMT2ASCN9AREN
SCHEMBL5891890	0.80	FNTB (0.39)	—

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-0666844-B1	INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE	MERCK & CO INC (US)	2000-08-23	—	—	EP	disclosed
EP-0666844-A1	INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE	MERCK & CO. INC. (US)	1995-08-16	—	—	EP	disclosed
WO-1994010138-A1	INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE	MERCK & CO., INC. (US)	1994-05-11	—	—	WO	disclosed