Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | REN | P00797 | 6/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8065171 | 0.90 | SYK (0.35) | KMT2ASYKSCN9AATMADORA1 | |
| SCHEMBL8065165 | 0.87 | KMT2A (0.32) | KMT2ASYKSCN9AATMADORA1 | |
| SCHEMBL8079819 | 0.86 | KMT2A (0.39) | KMT2ASCN9AATMRENMEN1 | |
| SCHEMBL5891423 | 0.86 | FNTA (0.39) | KMT2ASCN9AATMREN | |
| SCHEMBL8079882 | 0.86 | FNTA (0.39) | KMT2ASCN9AATMREN | |
| SCHEMBL8075177 | 0.85 | KDM4E (0.34) | SCN9AADORA1REN | |
| SCHEMBL8075650 | 0.84 | CTRB1 (0.34) | SCN9AADORA1REN | |
| SCHEMBL8075466 | 0.84 | SCN9A (0.33) | SCN9AADORA1REN | |
| SCHEMBL8961398 | 0.81 | SCN9A (0.45) | KMT2ASCN9AREN | |
| SCHEMBL5891931 | 0.80 | FNTB (0.40) | KMT2AMEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0666844-B1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2000-08-23 | — | — | EP | disclosed |
| WO-1994010138-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1994-05-11 | — | — | WO | disclosed |