Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 6/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 4/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PRKDC | P78527 | 4/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.38 |
| ▸ | MTOR | P42345 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | THRB | P10828 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | RECQL | P46063 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL645693 | 0.83 | EGFR (0.47) | EGFRMAPTKMT2AMEN1GAA | |
| SCHEMBL10188125 | 0.78 | EGFR (0.47) | EGFRMAPTKMT2AMEN1GAA | |
| SCHEMBL6836909 | 0.74 | RAB9A (0.52) | EGFRMAPTKMT2AMEN1GAA | |
| SCHEMBL10188150 | 0.71 | ALPL (0.51) | EGFRMAPTKMT2AMEN1GAA | |
| SCHEMBL17683162 | 0.71 | ROCK1 (0.47) | EGFRMAPTKMT2AMEN1GAA | |
| SCHEMBL21676903 | 0.71 | ROCK1 (0.47) | EGFRMAPTKMT2AMEN1GAA | |
| SCHEMBL30459783 | 0.71 | ROCK1 (0.47) | EGFRMAPTKMT2AMEN1GAA | |
| SCHEMBL30108000 | 0.69 | MAPT (0.53) | EGFRMAPTKMT2AMEN1GAA | |
| SCHEMBL20632859 | 0.69 | ROCK1 (0.45) | EGFRMAPTKMT2AMEN1GAA | |
| SCHEMBL7719696 | 0.68 | GAA (0.68) | EGFRMAPTKMT2AMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009038775-A1 | SUBSTITUTED BENZOIMIDAZOLYL-PYRAZINE COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2009-03-26 | — | — | WO | disclosed |