Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM5 | Q9NZQ8 | 11/20 | 0.42 |
| ▸ | TRPM4 | Q8TD43 | 7/20 | 0.42 |
| ▸ | HTR2A | P28223 | 3/20 | 0.38 |
| ▸ | HTR2C | P28335 | 3/20 | 0.38 |
| ▸ | HTR2B | P41595 | 3/20 | 0.38 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.38 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.38 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.38 |
| ▸ | CACNG3 | O60359 | 1/20 | 0.38 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.38 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.38 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.38 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.38 |
| ▸ | CACNG7 | P62955 | 1/20 | 0.38 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.38 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.38 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.38 |
| ▸ | CACNG1 | Q06432 | 1/20 | 0.38 |
| ▸ | CACNB2 | Q08289 | 1/20 | 0.38 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29673081 | 0.79 | HTR2C (0.41) | HTR2AHTR2CHTR2BADRB1HTR1A | |
| SCHEMBL24542989 | 0.79 | HTR2C (0.41) | HTR2AHTR2CHTR2BADRB1HTR1A | |
| SCHEMBL23088348 | 0.71 | AADAT (0.50) | TRPM5TRPM4HTR2AHTR2CHTR2B | |
| SCHEMBL12719040 | 0.71 | KDM1A (0.44) | HTR2A | |
| SCHEMBL1016046 | 0.71 | PNMT (0.41) | HTR2AHTR2CHTR2BSLC6A4 | |
| SCHEMBL23109818 | 0.70 | HTR2C (0.40) | TRPM5TRPM4HTR2AHTR2CHTR2B | |
| SCHEMBL28078962 | 0.70 | SRD5A1 (0.48) | HTR2AHTR2CHTR2BSLC6A4SRD5A1 | |
| SCHEMBL28095849 | 0.70 | SRD5A1 (0.48) | HTR2AHTR2CHTR2BSLC6A4SRD5A1 | |
| SCHEMBL12114954 | 0.69 | CHRNB2 (0.39) | HTR2AHTR2CHTR2BCACNB4CACNA1A | |
| SCHEMBL28939110 | 0.69 | HCRTR2 (0.44) | ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009037220-A1 | TRICYCLIC HETEROCYCLIC DERIVATIVES | N.V. ORGANON (NL) | 2009-03-26 | — | — | WO | disclosed |