SCHEMBL8065769

SCHEMBL8065769

CSC(=NC(=O)OC(C)(C)C)NNC(=O)NC(=O)OCc1ccccc1

nearest known ligand 0.43

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
SYK P43405 1/20 0.43
CTSK P43235 5/20 0.41
IDO1 P14902 1/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
ALDH1A1 P00352 1/20 0.40
NPC1 O15118 1/20 0.38
RAB9A P51151 1/20 0.38
POLB P06746 1/20 0.38
AKT1 P31749 1/20 0.37
MEN1 O00255 1/20 0.37
KMT2A Q03164 1/20 0.37
ATM Q13315 1/20 0.37
MAPT P10636 1/20 0.37
LMNA P02545 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7342215 0.91 SYK (0.46) SYKCTSKIDO1SMN1; SMN2ALDH1A1
SCHEMBL7342211 0.91 SYK (0.46) SYKCTSKIDO1SMN1; SMN2ALDH1A1
SCHEMBL8063409 0.90 ALDH1A1 (0.44) CTSKSMN1; SMN2ALDH1A1NPC1RAB9A
SCHEMBL8063735 0.83 L3MBTL1 (0.46) CTSKSMN1; SMN2ALDH1A1NPC1RAB9A
SCHEMBL7342218 0.81 SYK (0.46) SYKIDO1SMN1; SMN2ALDH1A1NPC1
SCHEMBL13533438 0.80 ALDH1A1 (0.49) SMN1; SMN2ALDH1A1NPC1RAB9APOLB
SCHEMBL858791 0.80 ALDH1A1 (0.49) SMN1; SMN2ALDH1A1NPC1RAB9APOLB
SCHEMBL858792 0.80 ALDH1A1 (0.49) SMN1; SMN2ALDH1A1NPC1RAB9APOLB
SCHEMBL7758927 0.78 ALDH1A1 (0.47) SMN1; SMN2ALDH1A1NPC1RAB9APOLB
SCHEMBL7758925 0.78 ALDH1A1 (0.47) SMN1; SMN2ALDH1A1NPC1RAB9APOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6162925-A Antibiotic for methicillin resistant bacteria RESEARCH CORPORATION TECH., INC. (US) 2000-12-19 US disclosed
US-6110925-A EFFECTIVE AGAINST STAPHYLOCOCCUS; ANTITUMOR AGENTS RESEARCH CORPORATION TECHNOLOGIES, INC. (US) 2000-08-29 US disclosed