Sugi Predict

Sugi Predict / Compounds / SCHEMBL806600

SCHEMBL806600

SCHEMBL806600

Cc1sc(Nc2cc3c(cc2F)OCO3)nc1C(=O)N1CCCC(C)C1C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ TRPC3 Q13507 11/20 1.00
▸ TRPC6 Q9Y210 11/20 1.00
▸ TRPA1 O75762 2/20 0.72
▸ CACNA1C Q13936 2/20 0.72
▸ SCN5A Q14524 2/20 0.72
▸ TRPV1 Q8NER1 2/20 0.72
▸ TRPV4 Q9HBA0 2/20 0.72
▸ HCRTR1 O43613 3/20 0.36
▸ SCD5 Q86SK9 2/20 0.36
▸ HCRTR2 O43614 2/20 0.36
▸ ALDH1A1 P00352 2/20 0.34
▸ MAPT P10636 2/20 0.34
▸ SMN1; SMN2 Q16637 1/20 0.34
▸ NPC1 O15118 1/20 0.34
▸ RAB9A P51151 1/20 0.34
▸ TP53 P04637 1/20 0.34
▸ POLB P06746 1/20 0.34
▸ TSHR P16473 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10087861 0.90 TRPC3 (1.00) TRPC3TRPC6TRPA1CACNA1CSCN5A
SCHEMBL26458201 0.89 TRPC3 (0.80) TRPC3TRPC6TRPA1CACNA1CSCN5A
SCHEMBL26458213 0.85 TRPC3 (0.83) TRPC3TRPC6TRPA1CACNA1CSCN5A
SCHEMBL26458205 0.85 TRPC3 (0.83) TRPC3TRPC6TRPA1CACNA1CSCN5A
SCHEMBL26459111 0.84 TRPC3 (1.00) TRPC3TRPC6TRPA1CACNA1CSCN5A
SCHEMBL30186173 0.84 TRPC3 (1.00) TRPC3TRPC6TRPA1CACNA1CSCN5A
SCHEMBL798463 0.84 TRPC3 (1.00) TRPC3TRPC6TRPA1CACNA1CSCN5A
SCHEMBL806596 0.83 TRPC3 (0.74) TRPC3TRPC6TRPA1CACNA1CSCN5A
SCHEMBL789038 0.81 TRPC3 (0.77) TRPC3TRPC6TRPA1CACNA1CSCN5A
SCHEMBL26458712 0.79 TRPC3 (0.80) TRPC3TRPC6TRPA1CACNA1CSCN5A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230137816-A1 ADMINISTRATION OF CALCIUM CHANNEL TRPC6 INHIBITORS USING BALLOONS, STENTS OR OTHER MEDICAL DEVICES DEUTSCHES HERZZENTRUM MUENCHEN DES FREISTAATES BAYERN (DE) 2023-05-04 — — US disclosed
US-20230137816-A1 ADMINISTRATION OF CALCIUM CHANNEL TRPC6 INHIBITORS USING BALLOONS, STENTS OR OTHER MEDICAL DEVICES DEUTSCHES HERZZENTRUM MUENCHEN DES FREISTAATES BAYERN (DE) 2023-05-04 — — US disclosed
WO-2021160625-A1 ADMINISTRATION OF CALCIUM CHANNEL TRPC6 INHIBITORS USING BALLOONS, STENTS OR OTHER MEDICAL DEVICES KLINIKUM RECHTS DER ISAR (DE) 2021-08-19 — — WO disclosed
WO-2012037351-A1 COMPOUNDS GLAXOSMITHKLINE LLC (US) 2012-03-22 — — WO disclosed
WO-2012037351-A1 COMPOUNDS GLAXOSMITHKLINE LLC (US) 2012-03-22 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230137816-A1 ADMINISTRATION OF CALCIUM CHANNEL TRPC6 INHIBITORS USING BALLOONS, STENTS OR OTHER MEDICAL DEVICES TRPC6, TRPC1, ORAI1 TRPC3 6/4885TRPC6 1/4885TRPA1 26/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.