Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 3/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | RORC | P51449 | 2/20 | 0.41 |
| ▸ | RORB | Q92753 | 2/20 | 0.41 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP4B1 | P13584 | 1/20 | 0.41 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17633592 | 0.80 | PDE4D (0.66) | PDE4BPDE4DHTR2ARORCRORB | |
| SCHEMBL4331079 | 0.80 | SLC6A4 (0.44) | PDE4BHTR2ASLC6A4KCNH2GAPDH | |
| SCHEMBL5099550 | 0.79 | PDE4D (0.56) | PDE4BPDE4DRORCRORBNPC1 | |
| SCHEMBL4326455 | 0.79 | HSPB1 (0.51) | PDE4BHDAC4HDAC2HDAC8PDE4D | |
| SCHEMBL29633976 | 0.77 | PDE4B (0.51) | PDE4BPDE4DNPC1SMN1; SMN2MAPK10 | |
| SCHEMBL3797410 | 0.76 | HTR7 (0.55) | PDE4BPDE4DRORCRORBCYP1A1 | |
| SCHEMBL28571515 | 0.75 | PDE4B (0.68) | PDE4BPDE4DKCNH2CYP3A4CYP2C9 | |
| SCHEMBL16290533 | 0.75 | CYP1A1 (0.49) | HDAC4HDAC2HDAC8CYP1A1CYP1A2 | |
| SCHEMBL3787052 | 0.75 | PDE4B (0.52) | PDE4BPDE4DRORCRORBNPC1 | |
| SCHEMBL3841461 | 0.74 | PDE4D (0.52) | PDE4BPDE4DRORCRORBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009067600-A2 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | WO | disclosed |