Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.41 |
| ▸ | HTR7 | P34969 | 4/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8065317 | 0.90 | PDE4D (0.47) | PDE4DPDE4BHTR7GABRA1GABRB2 | |
| SCHEMBL8065375 | 0.87 | PDE4D (0.47) | PDE4DPDE4BHTR7GABRA1GABRB2 | |
| SCHEMBL8067030 | 0.87 | PDE4D (0.49) | PDE4DPDE4BHTR7GABRA1GABRB2 | |
| SCHEMBL8066338 | 0.86 | PDE4D (0.53) | PDE4DPDE4BHTR7HDAC4HDAC2 | |
| SCHEMBL8067909 | 0.84 | PDE4D (0.45) | PDE4DPDE4BHTR7GABRA1GABRB2 | |
| SCHEMBL8066158 | 0.84 | PDE4D (0.48) | PDE4DPDE4BHTR7HDAC4HDAC2 | |
| SCHEMBL15906186 | 0.83 | TP53 (0.45) | PDE4DPDE4BHTR7GABRA1GABRB2 | |
| SCHEMBL8066904 | 0.80 | PDE4D (0.54) | PDE4DPDE4BHTR7HDAC4HDAC2 | |
| SCHEMBL8071940 | 0.80 | PDE4D (0.51) | PDE4DPDE4BHTR7HDAC4HDAC2 | |
| SCHEMBL13578467 | 0.80 | PDE4D (0.42) | PDE4DPDE4BHTR7GABRA1GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009067600-A2 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | WO | disclosed |