Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 2/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 3/20 | 0.41 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.39 |
| ▸ | CFD | P00746 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8066338 | 0.94 | PDE4D (0.53) | PDE4DPDE4BHDAC4HDAC2HDAC8 | |
| SCHEMBL8066925 | 0.87 | PDE4D (0.48) | PDE4DPDE4BHDAC4HDAC2HDAC8 | |
| SCHEMBL8066867 | 0.86 | PDE4B (0.46) | PDE4DPDE4BHDAC4HDAC2HDAC8 | |
| SCHEMBL8014205 | 0.86 | PDE4B (0.46) | PDE4DPDE4BHDAC4HDAC2HDAC8 | |
| SCHEMBL8066487 | 0.85 | PDE4D (0.41) | PDE4DPDE4BHDAC4HDAC2HDAC8 | |
| SCHEMBL8067827 | 0.83 | GAA (0.51) | PDE4DPDE4BFFAR1MEN1ALDH1A1 | |
| SCHEMBL8071940 | 0.82 | PDE4D (0.51) | PDE4DPDE4BHDAC4HDAC2HDAC8 | |
| SCHEMBL8066904 | 0.82 | PDE4D (0.54) | PDE4DPDE4BHDAC4HDAC2HDAC8 | |
| SCHEMBL8065375 | 0.80 | PDE4D (0.47) | PDE4DPDE4BHDAC4HDAC2HDAC8 | |
| SCHEMBL8065317 | 0.80 | PDE4D (0.47) | PDE4DPDE4BHDAC4HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009067600-A2 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | WO | disclosed |