Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | CTSA | P10619 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8031101 | 0.86 | HDAC4 (0.46) | MEN1KMT2AACHEMAPTCASP3 | |
| SCHEMBL15906120 | 0.83 | ACHE (0.52) | MEN1KMT2AACHEGRM5LMNA | |
| SCHEMBL14003503 | 0.81 | HSD17B10 (0.56) | MEN1KMT2AMAPTCASP3SENP7 | |
| SCHEMBL8071937 | 0.80 | PDE4B (0.47) | MEN1KMT2AMAPTHTR7LMNA | |
| SCHEMBL30728871 | 0.79 | ACHE (0.55) | MEN1KMT2AACHEMAPTGRM5 | |
| SCHEMBL7875685 | 0.79 | ACHE (0.55) | MEN1KMT2AACHEMAPTGRM5 | |
| SCHEMBL1673262 | 0.78 | PTGDR2 (0.58) | MEN1KMT2AACHEMAPTGRM5 | |
| SCHEMBL16710403 | 0.78 | FYN (0.49) | ACHEGRM5CTSAALDH1A1HDAC4 | |
| SCHEMBL14003309 | 0.78 | ALDH1A1 (0.50) | MEN1KMT2AACHEMAPTGRM5 | |
| SCHEMBL3787052 | 0.78 | PDE4B (0.52) | ACHEMAPTGRM5CTSASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009067600-A2 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | WO | disclosed |