Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.55 |
| ▸ | RAB9A | P51151 | 5/20 | 0.55 |
| ▸ | TRPC3 | Q13507 | 2/20 | 0.51 |
| ▸ | TRPC6 | Q9Y210 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10080532 | 0.90 | TRPC3 (0.54) | NPC1RAB9ATRPC3TRPC6HPGD | |
| SCHEMBL10080530 | 0.90 | TRPC3 (0.63) | NPC1RAB9ATRPC3TRPC6HPGD | |
| SCHEMBL806828 | 0.81 | TRPC3 (0.64) | NPC1RAB9ATRPC3TRPC6HPGD | |
| SCHEMBL10080527 | 0.80 | TRPC3 (0.66) | NPC1RAB9ATRPC3TRPC6HPGD | |
| SCHEMBL10080531 | 0.77 | TRPC3 (0.58) | NPC1RAB9ATRPC3TRPC6HPGD | |
| SCHEMBL807012 | 0.77 | TRPC3 (0.62) | NPC1RAB9ATRPC3TRPC6HPGD | |
| SCHEMBL10080528 | 0.73 | RAB9A (0.58) | NPC1RAB9ATRPC3TRPC6HPGD | |
| SCHEMBL10080529 | 0.70 | TRPC3 (0.58) | NPC1RAB9ATRPC3TRPC6HPGD | |
| SCHEMBL4923910 | 0.69 | KDM4E (0.58) | NPC1RAB9ATRPC3TRPC6HPGD | |
| SCHEMBL798510 | 0.68 | TRPC3 (0.67) | NPC1RAB9ATRPC3TRPC6HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012037349-A2 | COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |
| WO-2012037349-A2 | COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |