Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 16/20 | 0.60 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8068866 | 0.89 | MMP13 (0.57) | MMP13 | |
| SCHEMBL3694242 | 0.88 | MMP13 (0.62) | MMP13ROCK2ROCK1 | |
| SCHEMBL8069461 | 0.86 | MMP13 (0.58) | MMP13ROCK2ROCK1 | |
| SCHEMBL8057403 | 0.82 | MMP13 (0.62) | MMP13ROCK2ROCK1 | |
| SCHEMBL8071335 | 0.81 | MMP13 (0.58) | MMP13ROCK2ROCK1 | |
| SCHEMBL8066239 | 0.79 | MMP13 (0.72) | MMP13 | |
| SCHEMBL8056484 | 0.79 | MMP13 (0.53) | MMP13ROCK2ROCK1 | |
| SCHEMBL8068867 | 0.78 | MMP13 (0.72) | MMP13 | |
| SCHEMBL8069587 | 0.78 | MMP13 (0.72) | MMP13 | |
| SCHEMBL8065705 | 0.77 | MMP13 (0.87) | MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101815710-A | Pyrimidine and pyridine derivatives, their pharmaceutical use and compositions | PFIZER | 2010-08-25 | — | — | CN | disclosed |
| WO-2009016498-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS | PFIZER INC. (US) | 2009-02-05 | — | — | WO | disclosed |