Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 3/20 | 0.49 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.43 |
| ▸ | KDM6B | O15054 | 1/20 | 0.43 |
| ▸ | ALKBH2 | Q6NS38 | 1/20 | 0.43 |
| ▸ | ALKBH3 | Q96Q83 | 1/20 | 0.43 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.43 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.43 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.43 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.43 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.41 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | BCL2 | P10415 | 1/20 | 0.39 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9588560 | 0.80 | TDP1 (0.42) | HTTTRPA1KDM6B | |
| SCHEMBL9587896 | 0.80 | L3MBTL1 (0.46) | KDM6BTBXAS1 | |
| SCHEMBL9586673 | 0.79 | TDP1 (0.45) | KDM6BTBXAS1 | |
| SCHEMBL21803759 | 0.78 | CYP11B1 (0.43) | CYP11B1CYP11B2HTTCALM1BCL2 | |
| SCHEMBL21983945 | 0.78 | TAAR1 (0.50) | CYP11B1CYP11B2HTTTRPA1 | |
| Bromide SCHEMBL29018744 | 0.78 | KDM6B (0.44) | CYP11B1CYP11B2KDM6BALKBH2ALKBH3 | |
| SCHEMBL1501358 | 0.78 | ADRA2C (0.52) | CYP11B1CYP11B2HTTADRA2C | |
| SCHEMBL20385445 | 0.77 | LOXL2 (0.55) | CYP11B1CYP11B2KDM6BALKBH2ALKBH3 | |
| SCHEMBL4849854 | 0.77 | BCL2 (0.53) | CYP11B1CYP11B2KDM6BALKBH2ALKBH3 | |
| SCHEMBL9923548 | 0.77 | HTT (0.68) | CYP11B1CYP11B2HTTTBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230192607-A1 | TRANSCRIPTIONAL ENHANCED ASSOCIATE DOMAIN (TEAD) TRANSCRIPTION FACTOR INHIBITORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2023-06-22 | — | — | US | disclosed |
| CN-107001273-A | Pyridine derivate | 安斯泰来制药株式会社 | 2017-08-01 | — | — | CN | disclosed |
| US-6054469-A | Substituted tetrahydropyridine derivatives acting on 5-HT receptors | MERCK SHARP & DOHME LTD. (GB) | 2000-04-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230192607-A1 | TRANSCRIPTIONAL ENHANCED ASSOCIATE DOMAIN (TEAD) TRANSCRIPTION FACTOR INHIBITORS AND USES THEREOF | TEAD1, TEAD4, TEAD2 | CYP11B1 1220/4885CYP11B2 1470/4885HTT 1935/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.