Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC3 | Q13507 | 12/20 | 0.77 |
| ▸ | TRPC6 | Q9Y210 | 12/20 | 0.77 |
| ▸ | GRM5 | P41594 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.42 |
| ▸ | SPR | P35270 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23771772 | 0.87 | TRPC3 (1.00) | TRPC3TRPC6GRM5L3MBTL1MDM2 | |
| SCHEMBL806596 | 0.78 | TRPC3 (0.74) | TRPC3TRPC6NPC1RAB9A | |
| SCHEMBL23771823 | 0.71 | TRPC3 (1.00) | TRPC3TRPC6GRM5SPRNPC1 | |
| SCHEMBL807013 | 0.70 | TRPC3 (1.00) | TRPC3TRPC6L3MBTL1MDM2NPC1 | |
| SCHEMBL806707 | 0.69 | TRPC3 (0.60) | TRPC3TRPC6L3MBTL1NPC1ALDH1A1 | |
| SCHEMBL789250 | 0.68 | TRPC3 (0.70) | TRPC3TRPC6L3MBTL1NPC1ALDH1A1 | |
| SCHEMBL806828 | 0.68 | TRPC3 (0.64) | TRPC3TRPC6GRM5L3MBTL1MDM2 | |
| SCHEMBL10080529 | 0.68 | TRPC3 (0.58) | TRPC3TRPC6GRM5L3MBTL1MDM2 | |
| SCHEMBL23149500 | 0.66 | SPR (0.52) | TRPC3TRPC6GRM5SPRALDH1A1 | |
| SCHEMBL23771825 | 0.66 | TRPC3 (1.00) | TRPC3TRPC6NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012037349-A2 | COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |