SCHEMBL8069353

SCHEMBL8069353

CC(C)(C)OC(=O)C(Cc1ccccc1)C(O)C(N)[N+](=O)[O-]

nearest known ligand 0.45

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ITGA4 P13612 2/20 0.45
ITGB7 P26010 2/20 0.45
SLC1A3 P43003 1/20 0.40
SLC1A2 P43004 1/20 0.40
SLC1A1 P43005 1/20 0.40
LTA4H P09960 1/20 0.40
SLC7A5 Q01650 1/20 0.39
ATM Q13315 1/20 0.39
TDP1 Q9NUW8 2/20 0.38
KLK5 Q9Y337 1/20 0.38
POLB P06746 1/20 0.38
MAPT P10636 1/20 0.38
CPA1 P15085 3/20 0.38
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38
CTSS P25774 2/20 0.37
CTSL P07711 1/20 0.37
CTSB P07858 1/20 0.37
CTSK P43235 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7110654 0.85 MMP8 (0.45) SLC1A3SLC1A2SLC1A1SLC7A5CPA1
SCHEMBL28295654 0.82 SLC1A3 (0.44) ITGA4ITGB7SLC1A3SLC1A2SLC1A1
SCHEMBL8486317 0.82 SLC1A3 (0.44) ITGA4ITGB7SLC1A3SLC1A2SLC1A1
SCHEMBL4669804 0.82 SLC1A3 (0.44) ITGA4ITGB7SLC1A3SLC1A2SLC1A1
SCHEMBL6703242 0.82 SLC1A3 (0.49) ITGA4ITGB7SLC1A3SLC1A2SLC1A1
SCHEMBL5016667 0.82 SLC1A3 (0.49) ITGA4ITGB7SLC1A3SLC1A2SLC1A1
SCHEMBL9833389 0.80 ITGA4 (0.47) ITGA4ITGB7SLC1A3SLC1A2SLC1A1
SCHEMBL27613188 0.79 SLC1A3 (0.44) ITGA4ITGB7SLC1A3SLC1A2SLC1A1
SCHEMBL27608532 0.78 SLC1A3 (0.47) ITGA4ITGB7SLC1A3SLC1A2SLC1A1
SCHEMBL27773551 0.78 SLC1A1 (0.64) ITGA4ITGB7SLC1A3SLC1A2SLC1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE36718-E 3-AMINO-1-NITRO-4-PHENYL-2-BUTANOL DERIVATIVES KANEKA CORPORATION (JP) 2000-05-30 US claimed
US-5616726-A AN 3-AMINO-1-NITRO-4-PHENYL-2-BUTANOL BY ADDING NITROMETHANE STEREOSELECTIVELY IN THE PRESENCE OF A BASE TO AN OPTICAL ACTIVE AMINOALDEHYDE; CHEMICAL INTERMEDIATES FOR DRUGS; E.G. THE ANTICARCINOGENIC AGENT, BESTATIN KANEKA CORPORATION (JP) 1997-04-01 US claimed
EP-0657415-A1 OPTICALLY ACTIVE AMINO ALCOHOL DERIVATIVE AND PROCESS FOR PRODUCING THE SAME KANEKA CORPORATION (JP) 1995-06-14 EP claimed