Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.41 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.39 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.39 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26655167 | 0.84 | CYP2D6 (0.45) | KMT2AALDH1A1MEN1CYP2C9STAT3 | |
| SCHEMBL26655196 | 0.84 | CYP2D6 (0.45) | KMT2AALDH1A1MEN1CYP2C9STAT3 | |
| SCHEMBL7032005 | 0.84 | CYP2D6 (0.45) | KMT2AALDH1A1MEN1CYP2C9STAT3 | |
| SCHEMBL7166740 | 0.84 | CYP2D6 (0.45) | KMT2AALDH1A1MEN1CYP2C9STAT3 | |
| SCHEMBL942085 | 0.84 | DRD2 (0.46) | HPGDKMT2AADORA3ALDH1A1MEN1 | |
| SCHEMBL942084 | 0.84 | DRD2 (0.46) | HPGDKMT2AADORA3ALDH1A1MEN1 | |
| SCHEMBL9885083 | 0.84 | DRD2 (0.46) | HPGDKMT2AADORA3ALDH1A1MEN1 | |
| SCHEMBL23387620 | 0.82 | ALDH1A1 (0.48) | KMT2AALDH1A1MEN1CYP2C9LMNA | |
| SCHEMBL23387619 | 0.82 | ALDH1A1 (0.48) | KMT2AALDH1A1MEN1CYP2C9LMNA | |
| SCHEMBL20594887 | 0.81 | CYP2D6 (0.54) | HPGDKMT2AADORA3ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009016498-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS | PFIZER INC. (US) | 2009-02-05 | — | — | WO | disclosed |