SCHEMBL8069555

SCHEMBL8069555

Cc1cc(C)cc(C(=O)C(C)NCC(CC=O)c2ccc(Cl)c(Cl)c2)c1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.38
LMNA P02545 1/20 0.38
HTT P42858 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
HPGD P15428 1/20 0.36
S1PR2 O95136 2/20 0.33
S1PR4 O95977 2/20 0.33
S1PR3 Q99500 2/20 0.33
MDM2 Q00987 2/20 0.33
TACR1 P25103 2/20 0.33
CYP26A1 O43174 1/20 0.33
S1PR1 P21453 1/20 0.33
MEN1 O00255 2/20 0.32
CYP2C9 P11712 2/20 0.32
CYP2C19 P33261 2/20 0.32
KMT2A Q03164 2/20 0.32
CYP2D6 P10635 2/20 0.32
CYP1A2 P05177 1/20 0.32
SLC6A2 P23975 2/20 0.32
SLC6A4 P31645 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8063522 0.83 ALDH1A1 (0.38) ALDH1A1LMNAHTTSMN1; SMN2HPGD
SCHEMBL8063519 0.83 ALDH1A1 (0.38) ALDH1A1LMNAHTTSMN1; SMN2HPGD
SCHEMBL8053257 0.82 ALDH1A1 (0.37) ALDH1A1LMNAHTTSMN1; SMN2HPGD
SCHEMBL8063808 0.82 ALDH1A1 (0.37) ALDH1A1LMNAHTTSMN1; SMN2HPGD
SCHEMBL8069558 0.80 ALDH1A1 (0.38) ALDH1A1LMNAHTTSMN1; SMN2HPGD
SCHEMBL8063574 0.75 TACR2 (0.48) TACR1
SCHEMBL8053254 0.75 TACR2 (0.48) TACR1
SCHEMBL8580535 0.75 S1PR2 (0.43) ALDH1A1LMNAHTTSMN1; SMN2HPGD
SCHEMBL4471204 0.74 SLC6A2 (0.51) CYP2D6SLC6A2SLC6A4SLC6A3CYP3A4
SCHEMBL8067348 0.73 SLC6A2 (0.40) ALDH1A1LMNAHTTSMN1; SMN2HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6013652-A ANTIINFLAMMATORY AGENTS; ANALGESICS; ANTIHISTAMINES MERCK & CO., INC. (US) 2000-01-11 US disclosed
US-5962462-A COMPOUNDS WHICH INHIBIT THE ENTRY OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) INTO TARGET CELLS; DELAYING THE ONSET OF ACQUIRED IMMUNE DEFICIENCY SYNDROME (AIDS). MERCK & CO., INC. (US) 1999-10-05 US disclosed
WO-1998025605-A1 SPIRO-SUBSTITUTED AZACYCLES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY MERCK & CO., INC. (US) 1998-06-18 WO disclosed
EP-0702681-A1 SPIRO-SUBSTITUTED AZACYCLES AS NEUROKININ ANTAGONISTS MERCK & CO. INC. (US) 1996-03-27 EP disclosed
WO-1994029309-A1 SPIRO-SUBSTITUTED AZACYCLES AS NEUROKININ ANTAGONISTS MERCK & CO., INC. (US) 1994-12-22 WO disclosed