Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 3/20 | 0.42 |
| ▸ | MMP1 | P03956 | 4/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 4/20 | 0.35 |
| ▸ | MMP3 | P08254 | 3/20 | 0.35 |
| ▸ | MMP9 | P14780 | 3/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
| ▸ | MMP14 | P50281 | 1/20 | 0.35 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.34 |
| ▸ | FPR2 | P25090 | 1/20 | 0.31 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7900480 | 0.83 | PIK3CD (0.35) | MMP8MMP1PIK3CDMMP2MMP3 | |
| SCHEMBL12308797 | 0.81 | CTSD (0.37) | MMP8PIK3CDKDM4EKDM5CPHF8 | |
| SCHEMBL8215935 | 0.79 | HDAC3 (0.41) | MMP8MMP1PIK3CDMMP2MMP3 | |
| SCHEMBL24737242 | 0.79 | MCL1 (0.36) | MMP8MMP1PIK3CDMMP2MMP3 | |
| SCHEMBL20904149 | 0.78 | PIK3CD (0.32) | MMP8PIK3CD | |
| SCHEMBL12308834 | 0.76 | SMN1; SMN2 (0.39) | PIK3CDKDM4E | |
| SCHEMBL12308383 | 0.76 | ALDH1A1 (0.41) | PIK3CDKDM4EEGLN1 | |
| SCHEMBL12308836 | 0.76 | PIK3CD (0.39) | MMP8PIK3CDFPR2 | |
| SCHEMBL12308380 | 0.75 | ALDH1A1 (0.32) | MMP8PIK3CDKDM4E | |
| SCHEMBL12335222 | 0.75 | PIK3CD (0.31) | MMP8PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009036020-A1 | MEK INHIBITORS CONTAINING A ZINC BINDING MOIETY | CURIS, INC. (US) | 2009-03-19 | — | — | WO | disclosed |