Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 7/20 | 0.34 |
| ▸ | ABCC9 | O60706 | 4/20 | 0.34 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.34 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.34 |
| ▸ | KCNJ8 | Q15842 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KCNE1 | P15382 | 3/20 | 0.33 |
| ▸ | KCNQ1 | P51787 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KCND3 | Q9UK17 | 1/20 | 0.33 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8069718 | 1.00 | AKR1B1 (0.36) | AKR1B1KDM4EABCB1ABCC9ABCC8 | |
| SCHEMBL8069716 | 1.00 | AKR1B1 (0.36) | AKR1B1KDM4EABCB1ABCC9ABCC8 | |
| SCHEMBL8071780 | 0.83 | ABCC9 (0.37) | KDM4EABCB1ABCC9 | |
| SCHEMBL8071775 | 0.83 | ABCC9 (0.37) | KDM4EABCB1ABCC9 | |
| SCHEMBL8071776 | 0.83 | ABCC9 (0.37) | KDM4EABCB1ABCC9 | |
| SCHEMBL8069766 | 0.76 | TRPV4 (0.36) | AKR1B1ABCB1CYP3A4TRPV4 | |
| SCHEMBL8060716 | 0.75 | ABCC9 (0.36) | AKR1B1ABCC9KCNE1KCNQ1 | |
| SCHEMBL8060714 | 0.75 | ABCC9 (0.36) | AKR1B1ABCC9KCNE1KCNQ1 | |
| SCHEMBL8060720 | 0.75 | ABCC9 (0.36) | AKR1B1ABCC9KCNE1KCNQ1 | |
| SCHEMBL10642982 | 0.74 | KDM4E (0.60) | KDM4EABCB1ABCC9ABCC8KCNJ11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6071953-A | Sulfonamide-substituted chromans, processes for their preparation, their use as medicament or diagnostic aid, and medicament comprising them | HOECHST AKTIENGESELLSCHAFT (DE) | 2000-06-06 | — | — | US | disclosed |
| EP-0860440-A1 | Sulfonamido substituted chromane derivatives with potassium channel blocking activity | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-08-26 | — | — | EP | disclosed |