Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 13/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 2/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
| ▸ | TNKS | O95271 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.31 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8069713 | 0.76 | AKR1B1 (0.36) | TRPV4ABCB1AKR1B1CYP3A4 | |
| SCHEMBL8069716 | 0.76 | AKR1B1 (0.36) | TRPV4ABCB1AKR1B1CYP3A4 | |
| SCHEMBL8069718 | 0.76 | AKR1B1 (0.36) | TRPV4ABCB1AKR1B1CYP3A4 | |
| SCHEMBL13476208 | 0.75 | MAPT (0.38) | ABCB1 | |
| SCHEMBL8069749 | 0.75 | KDM1A (0.33) | AKR1B1 | |
| SCHEMBL9371324 | 0.74 | ABCB1 (0.56) | ABCB1 | |
| SCHEMBL482249 | 0.74 | ABCB1 (0.56) | ABCB1 | |
| SCHEMBL4023253 | 0.74 | ABCB1 (0.56) | ABCB1 | |
| SCHEMBL481900 | 0.74 | ABCB1 (0.56) | ABCB1 | |
| SCHEMBL482676 | 0.70 | ABCC9 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6071953-A | Sulfonamide-substituted chromans, processes for their preparation, their use as medicament or diagnostic aid, and medicament comprising them | HOECHST AKTIENGESELLSCHAFT (DE) | 2000-06-06 | — | — | US | disclosed |
| EP-0860440-A1 | Sulfonamido substituted chromane derivatives with potassium channel blocking activity | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-08-26 | — | — | EP | disclosed |