Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 1/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | AHR | P35869 | 1/20 | 0.41 |
| ▸ | RORC | P51449 | 2/20 | 0.40 |
| ▸ | RORB | Q92753 | 2/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.39 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4325615 | 0.85 | PDE4D (0.70) | PDE4DPDE4BALDH1A1GAAMAPT | |
| SCHEMBL15906099 | 0.85 | PDE4B (0.47) | PDE4DPDE4BMAPTNPC1RORC | |
| SCHEMBL4331307 | 0.84 | PDE4B (0.46) | PDE4DPDE4BMAPTNPC1RORC | |
| SCHEMBL8069704 | 0.83 | PDE4D (0.54) | PDE4DPDE4BALDH1A1GAAMAPT | |
| SCHEMBL13578684 | 0.81 | PDE4D (0.43) | PDE4DPDE4BMAPTMEN1KMT2A | |
| SCHEMBL16158722 | 0.81 | PDE4B (0.43) | PDE4DPDE4BALDH1A1GAAMAPT | |
| SCHEMBL8064607 | 0.80 | PDE4D (0.76) | PDE4DPDE4BALDH1A1GAAMAPT | |
| SCHEMBL3792062 | 0.79 | MAPT (0.44) | PDE4DPDE4BALDH1A1MAPTMEN1 | |
| SCHEMBL8024587 | 0.79 | PDE4D (0.55) | PDE4DPDE4BALDH1A1GAAMAPT | |
| SCHEMBL5099550 | 0.77 | PDE4D (0.56) | PDE4DPDE4BALDH1A1MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009067600-A2 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | WO | disclosed |