Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 1/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.46 |
| ▸ | RORC | P51449 | 2/20 | 0.45 |
| ▸ | RORB | Q92753 | 2/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.43 |
| ▸ | TUBB | P07437 | 1/20 | 0.43 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.43 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.43 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.43 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.43 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.43 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.43 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.43 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.43 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16158860 | 0.86 | RORC (0.50) | PDE4DHDAC8RORCRORBHSP90AA1 | |
| SCHEMBL3467803 | 0.85 | PDE4D (0.52) | PDE4DRORCRORBHSP90AA1HSP90AB1 | |
| SCHEMBL3467270 | 0.84 | PDE4D (0.54) | PDE4DHDAC8HSP90AA1HSP90AB1MEN1 | |
| SCHEMBL8030382 | 0.84 | PDE4D (0.62) | PDE4DHDAC8RORCRORBHSP90AA1 | |
| SCHEMBL8069704 | 0.83 | PDE4D (0.54) | PDE4DRORCRORBPDE4BMEN1 | |
| SCHEMBL3467022 | 0.81 | MAPT (0.49) | PDE4DRORCRORBMEN1KMT2A | |
| SCHEMBL6246669 | 0.81 | PDE4D (0.54) | PDE4DRORCRORBHSP90AA1HSP90AB1 | |
| SCHEMBL16712924 | 0.81 | PDE4D (0.54) | PDE4DHDAC8RORCRORBHSP90AA1 | |
| SCHEMBL8064607 | 0.80 | PDE4D (0.76) | PDE4DPDE4BMEN1KMT2AHPGD | |
| SCHEMBL8055713 | 0.79 | HDAC8 (0.44) | PDE4DHDAC8RORCRORBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009067600-A2 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | WO | disclosed |
| WO-2009067621-A1 | BIARYL PDE4 INHIBITORS FOR TREATING PULMONARY AND CARDIOVASCULAR DISORDERS | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | WO | disclosed |