SCHEMBL8070103

SCHEMBL8070103

Ic1ccc2c(c1N(c1ccccc1)c1ccccc1)Cc1ccccc1-2

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PNMT P11086 1/20 0.39
NPC1 O15118 2/20 0.35
RAB9A P51151 2/20 0.35
ALDH1A1 P00352 2/20 0.35
KDM4E B2RXH2 1/20 0.35
LMNA P02545 1/20 0.35
MAPT P10636 1/20 0.35
HPGD P15428 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
SRD5A2 P31213 1/20 0.35
PGR P06401 1/20 0.34
HTR7 P34969 2/20 0.33
HTR2B P41595 2/20 0.33
CYP1A2 P05177 1/20 0.33
CYP3A4 P08684 1/20 0.33
CYP2D6 P10635 1/20 0.33
CYP2C9 P11712 1/20 0.33
CYP2C19 P33261 1/20 0.33
HSD17B10 Q99714 1/20 0.33
KDR P35968 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28435765 0.82 PNMT (0.40) PNMTNPC1RAB9AALDH1A1KDM4E
SCHEMBL9811549 0.82 PNMT (0.40) PNMTNPC1RAB9AALDH1A1KDM4E
SCHEMBL7930923 0.75 PNMT (0.46) PNMTNPC1RAB9AALDH1A1KDM4E
SCHEMBL9811544 0.75 HSP90AA1 (0.38) PNMTNPC1RAB9AALDH1A1KDM4E
SCHEMBL30929930 0.75 PNMT (0.46) PNMTNPC1RAB9AALDH1A1KDM4E
SCHEMBL1478410 0.75 PNMT (0.46) PNMTNPC1RAB9AALDH1A1KDM4E
SCHEMBL1477131 0.75 PNMT (0.46) PNMTNPC1RAB9AALDH1A1KDM4E
Fluorene SCHEMBL3191531 0.74 MAOA (0.50) PNMTNPC1RAB9AALDH1A1KDM4E
Fluorene SCHEMBL28260816 0.74 MAOA (0.50) PNMTNPC1RAB9AALDH1A1KDM4E
SCHEMBL28416939 0.73 PNMT (0.45) PNMTNPC1RAB9AALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6100405-A Benzothiazole-containing two-photon chromophores exhibiting strong frequency upconversion THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE AIR FORCE (US) 2000-08-08 US disclosed