Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC3 | Q13507 | 6/20 | 0.58 |
| ▸ | TRPC6 | Q9Y210 | 6/20 | 0.58 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.43 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.43 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.43 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.42 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.42 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.42 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10080527 | 0.80 | TRPC3 (0.66) | TRPC3TRPC6MAPTLMNATRPA1 | |
| SCHEMBL806647 | 0.79 | TRPC3 (0.54) | TRPC3TRPC6MAPTHTTPOLB | |
| SCHEMBL10080530 | 0.76 | TRPC3 (0.63) | TRPC3TRPC6MAPTHTTGAA | |
| SCHEMBL807012 | 0.75 | TRPC3 (0.62) | TRPC3TRPC6MAPTTRPA1CACNA1C | |
| SCHEMBL807015 | 0.74 | TRPC3 (1.00) | TRPC3TRPC6MAPTTRPA1CACNA1C | |
| SCHEMBL10080532 | 0.71 | TRPC3 (0.54) | TRPC3TRPC6HTTLMNATAS1R3 | |
| SCHEMBL10080528 | 0.71 | RAB9A (0.58) | TRPC3TRPC6MAPTHTTLMNA | |
| SCHEMBL10080531 | 0.69 | TRPC3 (0.58) | TRPC3TRPC6HTTGAAL3MBTL1 | |
| SCHEMBL10087863 | 0.69 | TRPC3 (0.58) | TRPC3TRPC6MAPTHTTGAA | |
| SCHEMBL4923910 | 0.68 | KDM4E (0.58) | TRPC3TRPC6MAPTHTTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012037349-A2 | COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |